Tanshinone IIA Downregulates HMGB1 and TLR4 Expression in a Spinal Nerve Ligation Model of Neuropathic Pain
Figure 4
The expression of TNF-α, IF-1β, and IF-10 in spinal cords of SNL rats on the different postoperative days. (a) TNF-α was upregulated in the spinal cord of SNL rats ( versus sham group). After Tan IIA treatment, TNF-α expression reduced significantly ( versus model group). (b) IF-1β was upregulated in the spinal cord of SNL rats ( <0.05 versus sham group). After Tan IIA treatment, TNF-α expression reduced significantly ( versus model group). (c) IF-10 was downregulated in the spinal cord of SNL rats ( versus sham group). After Tan IIA treatment, TNF-α expression increased significantly ( versus model group). Data are shown as the mean ± S.D. SNL: spinal nerve ligation. TNF-α: tumor necrosis factor alpha. IF-1β: interleukin-1 beta. IF-10: interleukin-10. S.D standard deviation.
