Brazilian Red Propolis Induces Apoptosis-Like Cell Death and Decreases Migration Potential in Bladder Cancer Cells

Figure 4

BRP ethanolic extract increased DNA fragmentation in 5637 cells. (a) Flow cytometry graphs for TUNEL analysis of cells treated with 25, 50, 100, and 200 μg/mL of BRP ethanolic extract for 24 h. Control group (A), 25 μg/mL group (B), 50 μg/mL group (C), and 100 μg/mL group (D). (b) Percentage of cells with DNA fragmentation after treatment with 25, 50, and 100 μg/mL of BRP ethanolic extract for 24 h. Data are expressed as means ± SEM from three independent experiments. Different letters (A and B) indicate significant differences between the means and differences were considered significant at .

(a)

(b)