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Evidence-Based Complementary and Alternative Medicine
Volume 2014 (2014), Article ID 679259, 6 pages
http://dx.doi.org/10.1155/2014/679259
Research Article

Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats

1Department of Orthopedics, Chinese Orthopedics and Traumatology Research Institute, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China
2School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China
3School of Basic Medicine, Fujian Medical University, Fuzhou 350108, China
4Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China

Received 16 October 2013; Accepted 12 November 2013; Published 12 January 2014

Academic Editor: Bo Cui

Copyright © 2014 Weifeng Ji et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The present investigation examined the neuroprotective effect of Agaricus brasiliensis (AbS) against STZ-induced diabetic neuropathic pain in laboratory rats. STZ-induced diabetic rats were administered orally with AbS. Body weight, serum glucose, and behavioral parameters were measured before and at the end of the experiment to see the effect of AbS on these parameters. After 6 weeks of treatments, all animals were sacrificed to study various biochemical parameters. Treatment with AbS 80 mg/kg in diabetic animals showed significant increase in body weight, pain threshold, and paw withdrawal threshold and significant decrease in serum glucose, LPO and NO level, Na-K-ATPase level, and TNF-α and IL-1β level as compared to vehicle treated diabetic animals in dose and time dependent manner. AbS can offer pain relief in PDN. This may be of potential benefit in clinical practice for the management of diabetic neuropathy.