Proof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary Extract Sceletium tortuosum (Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer’s Dementia

Table 3

Zembrin extract on vital signs in healthy control subjects.

	Zembrin: means (SDs);			Placebo: means (SDs);
	Before	After	value	Before	After	value
Systolic BP	115.0 (13.2)	116.7 (15.8)	ns	117.5 (17.4)	116.3 (13.8)	ns
Diastolic BP	72.3 (8.7)	73.4 (10.4)	ns	76.0 (9.4)	74.5 (7.5)	ns
Pulse	73.4 (7.2)	74.6 (7.1)	ns	74.4 (11.9)	75.7 (9.3)	ns
Temperature	36.2 (0.2)	36.1 (0.2)	ns	36.3 (0.3)	36.3 (0.3)	ns
Weight (lbs)	163.1 (26.0)	162.6 (26.7)	ns	162.7 (26.0)	163.5 (26.8)	ns

Ns: not significant at level.