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Evidence-Based Complementary and Alternative Medicine
Volume 2014 (2014), Article ID 684508, 18 pages
http://dx.doi.org/10.1155/2014/684508
Review Article

Genus Caulophyllum: An Overview of Chemistry and Bioactivity

1Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China
2Pharmaceutical College, Harbin Medical University, Harbin 150086, China

Received 21 January 2014; Accepted 2 April 2014; Published 4 May 2014

Academic Editor: Yong Jiang

Copyright © 2014 Yong-Gang Xia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Recently, some promising advances have been achieved in understanding the chemistry, pharmacology, and action mechanisms of constituents from genus Caulophyllum. Despite this, there is to date no systematic review of those of genus Caulophyllum. This review covers naturally occurring alkaloids and saponins and those resulting from synthetic novel taspine derivatives. The paper further discussed several aspects of this genus, including pharmacological properties, mechanisms of action, pharmacokinetics, and cell membrane chromatography for activity screening. The aim of this paper is to provide a point of reference for pharmaceutical researchers to develop new drugs from constituents of Caulophyllum plants.