Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 703624, 8 pages
http://dx.doi.org/10.1155/2014/703624
Research Article

Protein Fractions from Korean Mistletoe (Viscum Album coloratum) Extract Induce Insulin Secretion from Pancreatic Beta Cells

1School of Life Sciences, Handong Global University, Pohang, Gyungbuk 791-708, Republic of Korea
2Department of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
3Department of Biological Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel

Received 23 February 2014; Accepted 22 April 2014; Published 14 May 2014

Academic Editor: Cicero L. T. Chang

Copyright © 2014 Ki-Wook Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Welsh, D. A. Nielsen, A. J. MacKrell, and D. F. Steiner, “Control of insulin gene expression in pancreatic β-cells and in an insulin-producing cell line, RIN-5F cells. II. Regulation of insulin mRNA stability,” The Journal of Biological Chemistry, vol. 260, no. 25, pp. 13590–13594, 1985. View at Google Scholar · View at Scopus
  2. P. O. Berggren and I. B. Leibiger, “Novel aspects on signal-transduction in the pancreatic beta-cell,” Nutrition, Metabolism & Cardiovascular Diseases, vol. 16, supplement 1, pp. S7–S10, 2006. View at Publisher · View at Google Scholar
  3. P. M. Jones and S. J. Persaud, “Protein kinases, protein phosphorylation, and the regulation of insulin secretion from pancreatic β-cells,” Endocrine Reviews, vol. 19, no. 4, pp. 429–461, 1998. View at Google Scholar · View at Scopus
  4. S. K. Chakrabarti and R. G. Mirmira, “Transcription factors direct the development and function of pancreatic β cells,” Trends in Endocrinology and Metabolism, vol. 14, no. 2, pp. 78–84, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. “Diagnosis and classification of diabetes mellitus,” Diabetes Care, vol. 27, supplement 1, pp. S5–S10, 2004. View at Publisher · View at Google Scholar
  6. E. J. Weringer and A. A. Like, “Immune attack on pancreatic islet transplants in the spontaneously diabetic BioBreeding/Worcester (BB/W) rat is not MHC restricted,” Journal of Immunology, vol. 134, no. 4, pp. 2383–2386, 1985. View at Google Scholar · View at Scopus
  7. W. T. Cade, “Diabetes-related microvascular and macrovascular diseases in the physical therapy setting,” Physical Therapy, vol. 88, no. 11, pp. 1322–1335, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Brownlee, “Biochemistry and molecular cell biology of diabetic complications,” Nature, vol. 414, no. 6865, pp. 813–820, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. A. R. Andersen, J. S. Christiansen, J. K. Andersen, S. Kreiner, and T. Deckert, “Diabetic nephropathy in type 1 (insulin-dependent) diabetes: an epidemiological study,” Diabetologia, vol. 25, no. 6, pp. 496–501, 1983. View at Google Scholar · View at Scopus
  10. D. E. deWitt and I. B. Hirsch, “Outpatient insulin therapy in type 1 and type 2 diabetes mellitus: scientific review,” Journal of the American Medical Association, vol. 289, no. 17, pp. 2254–2264, 2003. View at Google Scholar · View at Scopus
  11. Y. Ohkubo, H. Kishikawa, E. Araki et al., “Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study,” Diabetes Research and Clinical Practice, vol. 28, no. 2, pp. 103–117, 1995. View at Publisher · View at Google Scholar · View at Scopus
  12. M. A. Atkinson and G. S. Eisenbarth, “Type 1 diabetes: new perspectives on disease pathogenesis and treatment,” The Lancet, vol. 358, no. 9277, pp. 221–229, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. S. C. Shah, J. I. Malone, and N. E. Simpson, “A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus,” The New England Journal of Medicine, vol. 320, no. 9, pp. 550–554, 1989. View at Google Scholar · View at Scopus
  14. G. Stein, W. Henn, H. von Laue, and P. Berg, “Modulation of the cellular and humoral immune responses of tumor patients by mistletoe therapy,” European Journal of Medical Research, vol. 3, no. 4, pp. 194–202, 1998. View at Google Scholar · View at Scopus
  15. J. Melzer, F. Iten, K. Hostanska, and R. Saller, “Efficacy and safety of mistletoe preparations (viscum album) for patients with cancer diseases,” Forschende Komplementarmedizin, vol. 16, no. 4, pp. 217–226, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. A. M. Gray and P. R. Flatt, “Insulin-secreting activity of the traditional antidiabetic plant Viscum album (mistletoe),” Journal of Endocrinology, vol. 160, no. 3, pp. 409–414, 1999. View at Google Scholar · View at Scopus
  17. B. Gerber, C. Scholz, T. Reimer, V. Briese, and W. Janni, “Complementary and alternative therapeutic approaches in patients with early breast cancer: a systematic review,” Breast Cancer Research and Treatment, vol. 95, no. 3, pp. 199–209, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. E. C. Lavelle, G. Grant, A. Pusztai et al., “Mistletoe lectins enhance immune responses to intranasally co-administered herpes simplex virus glycoprotein D2,” Immunology, vol. 107, no. 2, pp. 268–274, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. T. J. Yoon, Y. C. Yoo, T. B. Kang et al., “Cellular and humoral adjuvant activity of lectins isolated from Korean mistletoe (Viscum album colaratum),” International Immunopharmacology, vol. 1, no. 5, pp. 881–889, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. T. J. Yoon, Y. C. Yoo, T. B. Kang et al., “Prophylactic effect of Korean mistletoe (Viscum album coloratum) extract on tumor metastasis is mediated by enhancement of NK cell activity,” International Journal of Immunopharmacology, vol. 20, no. 4-5, pp. 163–172, 1998. View at Publisher · View at Google Scholar · View at Scopus
  21. T. J. Yoon, Y. C. Yoo, T. B. Kang et al., “Lectins isolated from Korean mistletoe (Viscum album coloratum) induce apoptosis in tumor cells,” Cancer Letters, vol. 136, no. 1, pp. 33–40, 1999. View at Publisher · View at Google Scholar · View at Scopus
  22. T. J. Yoon, Y. C. Yoo, T. B. Kang et al., “Antitumor activity of the Korean mistletoe lectin is attributed to activation of macrophages and NK cells,” Archives of Pharmacal Research, vol. 26, no. 10, pp. 861–867, 2003. View at Google Scholar · View at Scopus
  23. T. J. Yoon, Y. C. Yoo, O. B. Choi et al., “Inhibitory effect of Korean mistletoe (Viscum album coloratum) extract on tumour angiogenesis and metastasis of haematogenous and non-haematogenous tumour cells in mice,” Cancer Letters, vol. 97, no. 1, pp. 83–91, 1995. View at Publisher · View at Google Scholar · View at Scopus
  24. T. B. Kang, Y. C. Yoo, K. H. Lee et al., “Korean mistletoe lectin (KML-IIU) and its subchains induce nitric oxide (NO) production in murine macrophage cells,” Journal of Biomedical Science, vol. 15, no. 2, pp. 197–204, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. T. B. Kang, S. K. Song, T. J. Yoon et al., “Isolation and characterization of two Korean mistletoe lectins,” Journal of Biochemistry and Molecular Biology, vol. 40, no. 6, pp. 959–965, 2007. View at Google Scholar · View at Scopus
  26. H.-W. Rho, J.-N. Lee, H.-R. Kim, B.-H. Park, and J.-W. Park, “Protective mechanism of glucose against alloxan-induced β-cell damage: pivotal role of ATP,” Experimental and Molecular Medicine, vol. 32, no. 1, pp. 12–17, 2000. View at Google Scholar · View at Scopus
  27. B.-H. Park and J.-W. Park, “The protective effect of Amomum xanthoides extract against alloxan-induced diabetes through the suppression of NFκB activation,” Experimental and Molecular Medicine, vol. 33, no. 2, pp. 64–68, 2001. View at Google Scholar · View at Scopus
  28. T. Mandrup-Poulsen, “Apoptotic signal transduction pathways in diabetes,” Biochemical Pharmacology, vol. 66, no. 8, pp. 1433–1440, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Y. Lyu, J. H. Choi, H. J. Lee, W. B. Park, and G. J. Kim, “Korean mistletoe lectin promotes proliferation and invasion of trophoblast cells through regulation of Akt signaling,” Reproductive Toxicology, vol. 39, pp. 33–39, 2013. View at Publisher · View at Google Scholar