New Treatment for Alzheimer’s Disease, Kamikihito, Reverses Amyloid--Induced Progression of Tau Phosphorylation and Axonal Atrophy
Figure 1
Effect of KKT and KPL pretreatment on A-induced phosphorylation of tau. Cortical neurons were cultured for 3 days and then treated with vehicle solution, KKT (10 μg/mL), or KPL (1 μM). At 1 h after each treatment, the cells were treated with A (25–35) (10 μM) for 4 h (a) or 72 h (b). After A treatment, the cells were fixed and immunostained with an antibody against paired helical filament tau (PHF-tau). The PHF-tau fluorescence intensity was quantified for each treatment. (, One-way ANOVA, post hoc Bonferroni’s multiple comparison test).
