Evidence-Based Complementary and Alternative Medicine

Research Article

In Vivo Hypocholesterolemic Effect of MARDI Fermented Red Yeast Rice Water Extract in High Cholesterol Diet Fed Mice

Table 4

Relative expression of atherosclerosis related gene in blood of 60 mg/kg body weight of MFRYR (group 4) and CRYR (group 5) treated mice as compared to the untreated mice (group 2).


Genes	Group 4 (MFRYR 60 mg/kg body weight)	Group 5 (CRYR 60 mg/kg body weight)
Genes	Relative expression (fold change)

ATP-binding cassette transporter 1 (Abca1)	N.S	2.00 ± 0.02
Apolipoproteins-E (ApoE)	2.66 ± 0.11	3.68 ± 0.09
Chemokine (C-C motif) ligand 2 (CCL2)	N.S	−2.00 ± 0.03
CD44	N.S	−2.01 ± 0.01
Fibronectin (Fn1)	N.S	−2.03 ± 0.01
Integrin, alpha 2 (ITGA2)	N.S	−2.00 ± 0.03
Lipoprotein lipase (LPL)	N.S	−2.00 ± 0.02
Macrophage scavenger receptor 1 (MSR1)	N.S	−2.01 ± 0.04
Neuropeptide Y (Npy)	N.S	−3.85 ± 0.01
Prostaglandin-endoperoxide synthase 1 (PTGS1)	N.S	−2.00 ± 0.03
Selectin P (SELP)	N.S	−2.00 ± 0.05
Transforming growth factor, beta 2 (TGFB2)	N.S	−2.01 ± 0.02
Tumor necrosis factor (TNF)	N.S	−2.00 ± 0.01
Vascular cell adhesion molecule 1 (Vcam1)	N.S	−2.00 ± 0.01
Von Willebrand factor (Vwf)	−3.00 ± 0.13	−4.24 ± 0.12

N.S.: not significant, only fold change greater than ±2 was recorded and presented as significant results.