Coadministration of Pinellia ternata Can Significantly Reduce Aconitum carmichaelii to Inhibit CYP3A Activity in Rats

Figure 2

Concentration-time profiles of BP (a), 6′-OH-BP (b), and 1-PP (c) in rats after intravenous injection of 0.5 mgkg⁻¹ BPHCl. Prior to intravenous injection of BPHCl, the rats were pretreated with PCW (0.6 gkg⁻¹d⁻¹, p.o.), PCW-BX (1 : 1, 0.6 gkg⁻¹d⁻¹, p.o.), or saline once daily for 7 d. The data presented in this figure indicate mean ± SD ().

(a)  

(b)

(c)