Coadministration of Pinellia ternata Can Significantly Reduce Aconitum carmichaelii to Inhibit CYP3A Activity in Rats

Figure 3

Formation rates of 6β-OH-Tes from Tes in rat liver microsomes (RLMs). Before the RLMs were prepared, rats were pretreated with RCW (0.6 gkg⁻¹d⁻¹, p.o.), RCW-BX (1 : 1, 0.6 gkg⁻¹d⁻¹, p.o.), PCW (0.6 gkg⁻¹d⁻¹, p.o.), PCW-BX (1 : 1, 0.6 gkg⁻¹d⁻¹, p.o.), or saline once daily for 7 d. The rats were pretreated with SKF-525A hydrochloride (0.1 gkg⁻¹, 7 d, p.o.) as the positive control (PC) for CYP3A inhibition. and compared with the control group, compared with the RCW group, and compared with the PCW group. Data are expressed as mean SD.