Coadministration of Pinellia ternata Can Significantly Reduce Aconitum carmichaelii to Inhibit CYP3A Activity in Rats

Table 1

Pharmacokinetic parameters of BP, 1-PP, and 6′-OH-BP in rats after intravenous injection of 0.5 mg·kg⁻¹ BP·HCl. Prior to intravenous injection of BP·HCl, the rats were pretreated with RCW (0.6 g·kg⁻¹·d⁻¹, p.o.), RCW-BX (1 : 1, 0.6 g·kg⁻¹·d⁻¹, p.o.), PCW (0.6 g·kg⁻¹·d⁻¹, p.o.), PCW-BX (1 : 1, 0.6 g·kg⁻¹·d⁻¹, p.o.), or saline once daily for 7 d. The data presented in this figure indicate mean ± SD ().

Variable	Control	RCW	RCW-BX	PCW	PCW-BX
BP
(min·ng/mL)
(ng/mL)
(min)
CL (mL/min/kg)
(L/kg)
6′-OH-BP
(min·ng/mL)
(ng/mL)
(min)
(min)
CL (mL/min/kg)
(L/kg)
6′-OH-BP/BP
1-PP
(min·ng/mL)
(ng/mL)
(min)
(min)
CL (mL/min/kg)
(L/kg)
1-PP/BP

6′-OH-BP/BP means of 6′-OH-BP/ of BP; 1-PP/BP means of 1-PP/ of BP. compared with control group. compared with RCW group.