The Holistic Effects of Acupuncture Treatment

Table 2

Summary of experimental studies of acupuncture articles on proteomic technologies.

Author/year	Treatment manner	Disease	Acupoint	Testing technique	Upregulation protein	Downregulation protein
Bae et al./2013 [44]	Acupuncture	Kainic acid-induced neuronal destruction	HT8 (Shaofu)	2-dimensional electrophoresis	VCP	ULMAE-1, ATPS, HSP70, HSP4L, and CRMP-2
Lai et al./2012 [45]	Acupuncture	Hypertension	LR3	2-dimensional electrophoresis; and MALDI-TOF	Glutamate dehydrogenase 1, aldehyde dehydrogenase 2, glutathione S-transferase M5, Rho GDP dissociation inhibitor 1, DJ-1 protein, and superoxide dismutase	Heat shock protein-90,; synapsin-1, pyruvate kinase isozyme, NAD-dependent deacetylase sirtuin-2, protein kinase C inhibitor protein 1, ubiquitin hydrolase isozyme L1, and myelin basic protein
Gao et al./2012 [46]	Electroacupuncture	Chronic constrictive injury	ST36; GB34	2-dimensional electrophoresis and matrix-assisted laser desorption	19 hippocampal proteins which are involved in metabolic, physiological, and cellular processes
Pan et al./2011 [47]	Electroacupuncture	Acute ischemic stroke	MS6 (scalp acu motor areas); BL10 (Tianzhu); GB20 (Fengchi); LI4; PC6 (Neiguan); BL40 (Weizhong); SP6 (Sanyinjiao); ST36	2-DE + MS/MS	Gelsolin, C3	Serpin G1
Kim et al./2010 [48]	Acupuncture	Maternal separation	HT8	2-dimensional electrophoresis; and MALDI-TOF	Dpysl2, Drp2, Tuba1a, and Stx1b	N.A.
Li et al./2010 [49]	Electroacupuncture	Spinal cord injury (SCI)	GV6 (Jizhong); GV9 (Zhiyang)	2-dimensional electrophoresis; and MALDI-TOF	ANXA5, CRMP2	N.A.
Kim et al./2010 [50]	Electroacupuncture	Parkinson’s disease	GB34; GB39 (Xuanzhong)	2-dimensional electrophoresis; and MALDI-TOF	Cytochrome coxidase, subunit Vb	HAGH, cytosolic malate dehydrogenase Munc 18-1,; hydroxyacyl glutathione, and hydrolase
Jeon et al./2008 [51]	Electroacupuncture	Parkinson’s disease	GB34; SI3; BL62; ST36	2-dimensional electrophoresis	21 proteins	1 protein