Safety Evaluation of Oral Toxicity of Carica papaya Linn. Leaves: A Subchronic Toxicity Study in Sprague Dawley Rats
Table 3
Organ weight values of control group and rats treated with C. papaya leaf extract measured during the subchronic toxicity study. The relative organ weight per 100 g body weight recorded at the end of the study.
Organ
Control
0.01 g/kg BW
0.14 g/kg BW
2 g/kg BW
Male rats
Lung
0.31 ± 0.03
0.36 ± 0.09
0.37 ± 0.07
0.35 ± 0.08
Heart
0.27 ± 0.02
0.29 ± 0.05
0.27 ± 0.02
0.27 ± 0.03
Liver
2.87 ± 0.14
3.05 ± 0.66
2.80 ± 0.37
2.82 ± 0.27
Stomach
0.38 ± 0.03
0.38 ± 0.05
0.39 ± 0.06
0.37 ± 0.05
Spleen
0.13 ± 0.02
0.15 ± 0.01
0.15 ± 0.01
0.15 ± 0.03
GIT
0.34 ± 0.13
0.36 ± 0.08
0.28 ± 0.08
0.32 ± 0.09
Kidney (left)
0.31 ± 0.03
0.30 ± 0.06
0.29 ± 0.02
0.29 ± 0.03
Kidney (right)
0.32 ± 0.03
0.29 ± 0.05
0.29 ± 0.02
0.29 ± 0.03
Testis (left)
0.35 ± 0.03
0.34 ± 0.04
0.34 ± 0.03
0.35 ± 0.03
Testis (right)
0.35 ± 0.03
0.34 ± 0.04
0.35 ± 0.04
0.34 ± 0.02
Adrenal (left)
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
Adrenal (right)
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.00
0.00 ± 0.00
Female rats
Lung
0.46 ± 0.06
0.45 ± 0.09
0.44 ± 0.07
0.45 ± 0.09
Heart
0.32 ± 0.03
0.31 ± 0.02
0.31 ± 0.02
0.31 ± 0.03
Liver
2.95 ± 0.30
3.02 ± 0.27
2.85 ± 0.19
3.02 ± 0.26
Stomach
0.50 ± 0.07
0.46 ± 0.07
0.51 ± 0.08
0.49 ± 0.08
Spleen
0.17 ± 0.02
0.17 ± 0.02
0.18 ± 0.02
0.18 ± 0.02
GIT
0.45 ± 0.12
0.45 ± 0.18
0.43 ± 0.06
0.39 ± 0.04
Kidney (left)
0.30 ± 0.03
0.29 ± 0.04
0.29 ± 0.03
0.31 ± 0.03
Kidney (right)
0.31 ± 0.03
0.31 ± 0.03
0.30 ± 0.02
0.31 ± 0.02
Ovary (left)
0.02 ± 0.01
0.02 ± 0.00
0.02 ± 0.01
0.04 ± 0.06
Ovary (right)
0.02 ± 0.00
0.02 ± 0.00
0.02 ± 0.01
0.02 ± 0.01
Adrenal (left)
0.01 ± 0.00
0.02 ± 0.00
0.01 ± 0.01
0.01 ± 0.00
Adrenal (right)
0.01 ± 0.01
0.01 ± 0.00
0.01 ± 0.00
0.01 ± 0.01
Values are expressed as mean ± standard deviation (/group).
