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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 765413, 7 pages
http://dx.doi.org/10.1155/2014/765413
Research Article

Acupuncture Modulates the Functional Connectivity of the Default Mode Network in Stroke Patients

1Department of Neurology and Stroke Center, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China
2Department of Radiology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China
3Department of Acupuncture, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China
4The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710048, China

Received 28 December 2013; Revised 23 January 2014; Accepted 27 January 2014; Published 5 March 2014

Academic Editor: Baixiao Zhao

Copyright © 2014 Yong Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Abundant evidence from previous fMRI studies on acupuncture has revealed significant modulatory effects at widespread brain regions. However, few reports on the modulation to the default mode network (DMN) of stroke patients have been investigated in the field of acupuncture. To study the modulatory effects of acupuncture on the DMN of stroke patients, eight right hemispheric infarction and stable ischemic stroke patients and ten healthy subjects were recruited to undergo resting state fMRI scanning before and after acupuncture stimulation. Functional connectivity analysis was applied with the bilateral posterior cingulate cortices chosen as the seed regions. The main finding demonstrated that the interregional interactions between the ACC and PCC especially enhanced after acupuncture at GB34 in stroke patients, compared with healthy controls. The results indicated that the possible mechanisms of the modulatory effects of acupuncture on the DMN of stroke patients could be interpreted in terms of cognitive ability and motor function recovery.