Apocynum Tablet Protects against Cardiac Hypertrophy via Inhibiting AKT and ERK1/2 Phosphorylation after Pressure Overload
Table 1
Anatomical data of the four groups.
Group
NS-SHAM ()
NS-TAC ()
LBM-SHAM ()
LBM-TAC ()
BW, g
23 ± 0.3
23 ± 0.4
22 ± 0.3
23 ± 0.2
HW, mg
116.5 ± 3.8
151.2 ± 5.7***
106.6 ± 4.0
128.6 ± 3.7*##
LVW, mg
78.7 ± 3.9
104.5 ± 8.9**
57.7 ± 9.5
92.4 ± 2.9**#
Lung, mg
135.7 ± 3.2
147.9 ± 8.7
167.7 ± 10.4
154.6 ± 5.8
Liver, mg
876.0 ± 17.5
1054.6 ± 47.1
948.5 ± 51.7
980.4 ± 33.5
TL, mm
17.4 ± 0.2
17.3 ± 0.1
17.1 ± 0.1
17.1 ± 0.1
HW/BW
5.1 ± 0.2
6.5 ± 0.3**
4.8 ± 0.1
5.6 ± 0.1#
HW/TL
6.7 ± 0.2
8.8 ± 0.3***
6.2 ± 0.2
7.5 ± 0.2*##
LVW/TL
4.5 ± 0.2
6.1 ± 0.5**
3.4 ± 0.6
5.4 ± 0.2**#
Lung/BW
5.9 ± 0.1
6.4 ± 0.5
7.6 ± 0.6
6.7 ± 0.3
Liver/BW
38.4 ± 0.6
48.9 ± 2.4
42.3 ± 1.7
42.5 ± 1.5
NS: saline; AT: apocynum tablets; TAC: transverse aortic constriction; BW: body weight; HW: heart weight; LVW: left ventricular weight; TL: tibial length; *, **, and *** compared to NS-SHAM or AT-SHAM from the same group. #, ##, compared to AT-TAC from NS-TAC group.
