Synergistic Effects of Clopidogrel and Fufang Danshen Dripping Pills by Modulation of the Metabolism Target and Pharmacokinetics

Table 2

The max, mean, median, min, mode, and standard deviation (SD) values of the key descriptors for the one hundred twenty-seven compounds found in the FDDP.

	Minimum	Maximum	Mean	Median	Mode	Standard deviation
AlogP	−4.74	10.86	3.70	3.80	−0.62	2.74
Estate	21.50	273.99	63.31	50.25	24.83	51.35
ROF	0	3	0.74	0	0	0.94
HBA	0.00	27.00	4.08	3.00	0.00	5.36
HBD	0.00	17.00	2.03	0.00	0.00	3.60
MR	18.98	288.70	97.88	82.97	67.26	52.32
MW	116.07	827.38	352.39	284.48	204.35	222.60
PHOA	0	100	79.47	100	100	34.75
PSA	0.00	436.21	73.96	43.37	0.00	90.98
Polar	8.06	117.25	40.79	35.94	26.37	21.18
RB	0.00	20.00	4.72	1.00	0.00	5.62

AlogP: calculate atomic logP; Estate: calculate electrotopological states; HBA: number of hydrogen bond acceptors; HBD: number of hydrogen bond donors; MW: calculate molecular weight; MR: calculate molar refractivity; PHOA: percent human oral absorption; Polarity: calculate Miller polarisability; PSA: calculate polar surface area;　RB: calculate the number of rotatable bonds; ROF: rule of five.