Research Article
Synergistic Effects of Clopidogrel and Fufang Danshen Dripping Pills by Modulation of the Metabolism Target and Pharmacokinetics
Table 6
Pharmacokinetic parameters of the carboxylic acid metabolite of clopidogrel after intragastric administration of clopidogrel alone or coadministered with Fufang Danshen to rats at doses of 324 mg/kgand 30 mg/kg, respectively.
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(mg/L): maximum plasma concentration; (h): time to reach maximum concentration; MRT: mean residence time; MAT: mean absorption time; /: apparent distribution volume; CL/: apparent clearance; AUC: the area under the concentration time curve; (0–∞): from time zero to infinity; (0–tn): from time zero to last sampling time; when compared with the related parameters of analyte in the clopidogrel-only group. |