Synergistic Effects of Clopidogrel and Fufang Danshen Dripping Pills by Modulation of the Metabolism Target and Pharmacokinetics

Table 6

Pharmacokinetic parameters of the carboxylic acid metabolite of clopidogrel after intragastric administration of clopidogrel alone or coadministered with Fufang Danshen to rats at doses of 324 mg/kgand 30 mg/kg, respectively.

Parameter	Administered alone	Coadministration
(h)
(mg/L)	15. one hundred twenty-seven ± 3.809
AUC (0–tn) (mg/L*h)
AUC (0–∞) (mg/L*h)
MRT (0–tn) (h)
MRT (0–∞) (h)
MAT (h)
Ka
/ (L/kg)
1/2β (h)
CL/ (L/h/kg)

(mg/L): maximum plasma concentration; (h): time to reach maximum concentration; MRT: mean residence time; MAT: mean absorption time; /: apparent distribution volume; CL/: apparent clearance; AUC: the area under the concentration time curve; (0–∞): from time zero to infinity; (0–tn): from time zero to last sampling time; when compared with the related parameters of analyte in the clopidogrel-only group.