Evidence-Based Complementary and Alternative Medicine / 2014 / Article / Tab 2

Review Article

Pharmacopuncture for Cancer Care: A Systematic Review

Table 2

Characteristics of the included studies: chemotherapy-induced nausea and vomiting (CINV).

AuthorSample size (M/F)
Cancer type
Intervention Control Outcome measuresResult
InterventionControl

Liu et al. 2011 [24]51 (27/24)  
Hematologic cancer
Promethazine (25 mg) injection at bilateral ST36 Metoclopramide (10 mg), IV   Responder rate (%)a96.2%*68%
Yang et al. 2011 [25]96 (50/46)  
Various
Metoclopramide (10 mg) injection at bilateral ST36
0.5 h before chemotherapy, qd
Tropisetron (5 mg), IV
0.5 h before chemotherapy, bid
Responder rate (%)b78%*52.1%
You et al. 2009 [26]142 (0/142)  
Ovarian cancer
Vit. B6 (50 mg) injection and MA at bilateral PC6
qod
(1) Vit. B6 (50 mg), IM  
bid 
(2) MA at bilateral PC6
qod
(A) Total number of emesis episodes in 21 days (mean, 95% CI)  
(B) Proportion of emesis free days in 21 days (%, mean, 95% CI)
(A) 5.9, 3.8–7.0**  
(B) 59%, 48–69**
(1) (A) 13.2, 9.4–15.0 (B) 21%, 12–28 
(2) (A) 10.6, 7.4–11.8 (B) 30%, 21–39
Chen 2007 [27]258 (0/258)  
Ovarian cancer
Metoclopramide injection
10 mg, at left PC6 and CV10, 15 min before chemotherapy 
10 mg, at right PC6 and CV 10 after chemotherapy
(1) Metoclopramide, IV
20 mg each, before and after chemotherapy 
(2) Granisetron (3 mg), IV
before chemotherapy
Responder rate (%)c95%**(1) 40.5% 
(2) 96.5%
Hu 2003 [28]123 (86/37)  
Various
Huangqi or Danggui (4 mL) injection, alternately at bilateral ST36, SP10, and BL23
qd
Batilol (50 mg), leucogen (20 mg) and Vit. B6 (20 mg), po
tid
Responder rate (%)b71.8%**44.2%
Tao et al. 2000 [29]480 (343/137)  
Various
Metoclopramide (5 mg) and diazepam (1.25 mg) injection alternately at bilateral PC6 and ST36
30 min before chemotherapy 
Metoclopramide (10 mg) after chemotherapy
(1) Metoclopramide (20 mg) and diazepam (5 mg), IV
30 min before chemotherapy 
Metoclopramide (20 mg) after chemotherapy 
(2) Ondansetron, IV
8 mg, 30 min before chemotherapy 
8 mg, after chemotherapy
Responder rate (%)d98.8%**(1) 43.1% 
(2) 94.4%

AEs: adverse events; bid: twice a day; CI: confidence interval; h: hour(s); IM: intramuscular injection; IV: intravenous injection; MA: manual acupuncture; min: minute(s); NR: not reported; po: orally; qd: everyday; qod: every other day; Vit.: vitamin; WHO: World Health Organization.
Acupuncture point ST36 refers to 36th point of stomach meridian and extra points have different nomenclature (e.g., Ex-UE7 means 7th extra point in upper extremity).
aResponder rate: (number of participants with any improvement from the intervention/total number of participants) * 100(%).
bResponder rate: (number of participants with WHO grade [30] 0 + 1/total number of participants) * 100(%).
cResponder rate: (number of participants with less than four emesis episodes per day/total number of participants) * 100(%).
dResponder rate: (number of participants with less than three emesis episodes per day/total number of participants)*100 (%).
* ; ** .