Evidence-Based Complementary and Alternative Medicine / 2014 / Article / Tab 3

Review Article

Pharmacopuncture for Cancer Care: A Systematic Review

Table 3

Characteristics of the Included Studies: Ileus, Hiccup, Fever, QOL, Gastrointestinal Symptoms.

AuthorSample Size (M/F)
Cancer Type
Intervention Control Outcome MeasuresResult
InterventionControl

Ileus    
Chen et al. 2010 [31]120 (96/24) 
Rectal cancer
Neostigmine injection (0.5 mL) at bilateral ST36
bid 
Routine post-operative therapy
Routine post-operative therapy Time that the patient first passed a bowel movement (h, mean ± SD)45.1 ± 8.6*74.7 ± 16.3
Feng et al. 2007 [32]160 (92/68)  
Colon cancer
Vit. B1 injection (50 mg) at bilateral ST36
on the day of surgery
Vit. B1 (100 mg), IM ( = 80)  
on the day of surgery
Time that the patient first passed a bowel movement (h, mean ± SD) 29.6 ± 3.248.1 ± 5.3

Hiccup
Sui and Zhang 2009 [33]47 (31/16)  
Various
Anisodamine injection (10 mg) at ST36
bid
Anisodamine (10 mg), IM ( = 22)  
bid
Responder rate (%)76%*36.4%
Xia et al. 2000 [34]32 (20/12)  
Various
Atropine injection (1.25 mg) at bilateral ST36, Vit. B1 (10 mg), B12 (10 mg) at bilateral BL17 Atropine po (0.3 mg), tid or IM (0.5 mg) Responder rate (%)93.8%68.8%

Fever
Yan et al. 1999 [35]28 (21/7)  
Various
rIL-2 injection (50,000  /2 mL) at ST36
qd
rIL-2 (100,000  /2 mL), IM
qd
Responder rate (%)85.7%*50%
Yan et al. 1997 [36]58 (43/15)  
Upper GI cancer
Dexamethasone injection (1 mL) alternately at bilateral ST36
qd
Dexamethasone (10 mg), IM ( = 30)  
tid
Responder rate (%)89.3%**56.7%

QOL
Xue 2005 [37]108 (78/30)  
Various
Huangqi injection (2 mL) alternately at bilateral ST36
qd
Energy synbiotics, IV ( = 48)  
qd 
Lipid and albumin, twice a week
Responder rate (%, Karnofsky score) 50%**25%

GI Symptoms
Zhao et al. 2008 [38]30 (11/19)  
Various
Metoclopramide injection (10 mg) at bilateral ST36
qd 
Routine chemotherapy
Metoclopramide (10 mg), IM
qd 
Routine chemotherapy
WHO grade [30] 0, 1, 2, 3, 4 (number of patients)Grade 0: 1 
Grade 1: 6 
Grade 2: 8 
Grade 3: 0 
Grade 4: 0 
Grade 0: 0 
Grade 1: 4 
Grade 2: 9 
Grade 3: 2 
Grade 4: 0 

Abbreviation: AEs: adverse events; bid: twice a day; GI: gastrointestinal; h: hour(s); IM: intramuscular injection; IV: intravenous injection; min: minute(s); NR: not reported; po: orally; qd: everyday; QOL: quality of life; rIL-2: recombinant human interleukin-2; SD: standard deviation; tid: three times a day; Vit.: vitamin; WHO: World Health Organization.
Acupuncture point ST36 refers to 36th point of stomach meridian and extra points have different nomenclature (e.g., Ex-UE7 means 7th extra point in upper extremity).
Responder rate: (number of participants with any improvement from the intervention/total number of participants) * 100(%) unless stated otherwise.
* ; ** .