Evidence-Based Complementary and Alternative Medicine / 2014 / Article / Tab 5

Review Article

Pharmacopuncture for Cancer Care: A Systematic Review

Table 5

Reported AEs in the included studies.

Author
Sample Size* (Int./Cont.)
ConditionIntervention groupControl group

Reported “No AEs” for intervention group
 Liu et al. 2011 [24]CINVNo AEs occurredNo AEs occurred
 Yang et al. 2011 [25]CINVNo AEs occurredNR
 Chen 2007 [27]CINVNo AEs occurredNR
 Xue 2005 [37]QOLNo AEs occurredNR
 Shen 2009 [18] 
 23/25
PainNo AEs occurredConstipation (9), nausea and vomiting (6), dizziness (3)

Identical Drug Used for Both Groups
 Liu 2010 [16] 
 28/19
PainNausea and vomiting (1), headache and dizziness (2)
Resolved after the end of treatment
Nausea and vomiting (3), headache and dizziness (5), drowsiness and fatigue (2)
Resolved after the end of treatment
 Sui and Zhang 2009 [33] 
 25/22
HiccupXerostomia (9)
Resolved after the end of treatment
Xerostomia (10)
Resolved after the end of treatment
 Tao et al. 2000 [29]** 
 160/160
CINVHeadache and dizziness (26), bloating and constipation (4), and diarrhea (6)
Resolved after the end of treatment
Headache and dizziness (33), bloating and constipation (9), and diarrhea (20)
Resolved after the end of treatment
 Yan et al. 1997 [36] 
 28/30
FeverLocal pain and limitation of lower limb movement (5)
Resolved after the end of treatment
Insomnia and increased talkativeness (8) and panhidrosis (2)
Did not affect further treatment

Different Drugs Used for Each Groups
 Wang et al. 2004a*** [20]PainXerostomia, hot flashes, and blurred vision
Relieved spontaneously
Nausea, vomiting, constipation, and urinary retention
Mild and tolerable level
 Wang et al. 2004b*** [21]PainXerostomia, hot flashes, and blurred vision
Relieved spontaneously
Temporary low blood sugar
Continued treatment after glucose IV injection or a meal
Nausea, vomiting, constipation, and urinary retention
Mild and tolerable level
 Tao et al. 2000 [29]** 
 160/160
CINVHeadache and dizziness (26), bloating and constipation (4), and diarrhea (6)
Resolved after the end of treatment
Headache and dizziness (29), bloating and constipation (22), and diarrhea (5)
Resolved after the end of treatment

AEs: adverse events; CINV: chemotherapy-induced nausea and vomiting; Cont.: control group; Int.: intervention group; IV: intravenous; NR: not reported; QOL: quality of life.
Number in the parenthesis is reported number of cases.
*Sample size is reported on this table for studies with numerical data only.
**Two different control groups yielded two separate documentations in this table.
***Number of cases for symptoms were not reported.