Multifunctional Effects of Mangosteen Pericarp on Cognition in C57BL/6J and Triple Transgenic Alzheimer’s Mice

Figure 3

Molecular effects of the MP diet in B6 mice. Representative immunostaining images of BDNF (a), p-tau (S202) (b), activated astrocytes (c), and microglia (d) in the B6 mouse hippocampus. (e) The systemic IL-6 level was determined by ELISA with mouse serum. The IL-6 level was greatly increased in the older B6 mice, which was significantly decreased by the MP diet. All of the deregulations in the older mice were ameliorated after MP treatment. = 3–5/group. Arrowheads indicate positive staining signals. ^##, comparison between the older and younger groups. , comparison between the regular and MP diet groups.

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