Multifunctional Effects of Mangosteen Pericarp on Cognition in C57BL/6J and Triple Transgenic Alzheimer’s Mice

Figure 4

MP diet attenuated the impairment in spatial memory retrieval in 3×Tg-AD mice. (a) The spatial learning ability was measured in the 3×Tg-AD mice from training days 1~4. The 3×Tg-AD mice showed a poor spatial learning ability at 13 months of age, but the MP diet attenuated the impairment in spatial learning ability. (b) The spatial learning acquisition was measured in the 3×Tg-AD mice. The poor spatial learning acquisition of 13-month-old 3×Tg-AD mice could not be rescued by the MP diet. (c) The retrieval of short-term memory in the 3×Tg-AD mice. The reduced time spent in the target quadrant of the 13-month-old 3×Tg-AD mice was significantly increased by the MP diet. (d) The retrieval of long-term memory in the 3×Tg-AD mice. The MP diet significantly increased the time spent in the target quadrant of the 13-month-old 3×Tg-AD mice. (e) The swimming velocity of the 3×Tg-AD mice. The MP diet had no influence on the reduced velocity of the 13-month-old 3×Tg-AD mice. Data are expressed as means ± SEM. = 16-17/group. , , and , compared with the 13-month-old mice treated with a regular diet.

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