Multifunctional Effects of Mangosteen Pericarp on Cognition in C57BL/6J and Triple Transgenic Alzheimer’s Mice

Figure 6

Effects of the MP diet on amyloid deposition, p-tau (S202/S262), and NR2A/NR2B in 3×Tg-AD mice. Immunostaining images of APP (a), A (b), and A (c) in the hippocampus of the mice. The levels of BACE1 (d) and NR2A/NR2B ratio (e) in the hippocampus identified by western blot. The MP diet significantly decreased the level of BACE1 and increased the level of the NR2A/NR2B ratio. Immunostaining images of p-tau (S202) (f) in the hippocampus of the mice. (g) The level of p-tau (S262) measured in the hippocampus by western blot. The MP diet greatly decreased the level of p-tau (S262). Scale bar = 100 μm and arrowheads indicate positive staining signals. Data are expressed as means ± SEM. = 3–5/group. , comparison between the regular and MP diet groups.

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