Multifunctional Effects of Mangosteen Pericarp on Cognition in C57BL/6J and Triple Transgenic Alzheimer’s Mice

Figure 7

The antioxidative and anti-inflammatory activities of MP in 3×Tg-AD mice. (a) The systemic GSH level was determined by ELISA with mouse serum. MP diet significantly increased the GSH level in the mouse serum. (b) The systemic IL-6 level was determined by ELISA with mouse serum. MP diet significantly decreased the IL-6 level in the mouse serum. (c) The level of pp38 was measured in the hippocampus of the mice by western blot. MP diet significantly decreased the level of pp38. (d) The level of COX2 was measured in the hippocampus of the mice by western blot. MP diet significantly decreased the level of COX2. Immunostaining images of activated astrocytes (e) and microglia (f) in the hippocampus. Scale bar = 100 μm and arrowheads indicate positive staining signals. Data are expressed as means ± SEM. = 3–5/group. and , comparison between the regular and MP diet groups.

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