Deciphering Molecular Mechanism Underlying Hypolipidemic Activity of Echinocystic Acid
Figure 2
Molecular docking of echinocystic acid (EA) with ACAT in 3D diagram. (a) Three-dimensional structure of ACAT. (b) Optimized docking conformation of EA in the hydrophobic pocket of ACAT. The surface of ACAT was color-coded by electrostatic potential. Red, positive charge; white, neutral; blue, negative charge. (c) Detailed binding mode of EA with ACAT. Dotted blue lines display the hydrogen bonding between the carboxyl group and OH group of EA and amino acid residues Gly 336 and Glu 340 of ACAT.
