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Evidence-Based Complementary and Alternative Medicine
Volume 2014 (2014), Article ID 835914, 8 pages
http://dx.doi.org/10.1155/2014/835914
Research Article

Anti-Inflammatory and Antihyperalgesic Activities of Ethanolic Extract and Fruticulin A from Salvia lachnostachys Leaves in Mice

1School of Health Sciences, Federal University of Grande Dourados (UFGD), Rodovia Dourados, Itahum, Km 12, Cidade Universitária, Caixa Postal 533, 79.804-970 Dourados, MS, Brazil
2School of Biological and Health Sciences, University Center of Grande Dourados, 79.824-900 Dourados, MS, Brazil
3Chemistry Department, Federal University of Paraná, 81531-980 Curitiba, PR, Brazil
4Botany Department, Federal University of Paraná, 81531-980 Curitiba, PR, Brazil
5“Dr. Hélio Mandetta” School of Medicine, Federal University of Mato Grosso do Sul, 79070-900 Campo Grande, MS, Brazil

Received 11 August 2014; Revised 10 October 2014; Accepted 12 October 2014; Published 10 November 2014

Academic Editor: Ke Ren

Copyright © 2014 Ana Claudia Piccinelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The anti-inflammatory and analgesic effects of the ethanolic extract (SLEE) and fruticulin A from the leaves of Salvia lachnostachys were evaluated in mice, using experimental models of inflammation (paw oedema and pleurisy induced by carrageenan injection) and hyperalgesia (electronic Von Frey). Oral administration of SLEE (30, 100, and 300 mg/kg) and fruticulin A (0.3 and 3.0 mg/kg) decreased the total leucocytes number in pleural lavage, protein extravasation, and paw oedema. SLEE (100 mg/kg) and fruticulin A (3 mg/kg) also exhibited antihyperalgesic activity in carrageenan induced mechanical hyperalgesia. In addition, fruticulin A (3 mg/kg) prevented mechanical hyperalgesia, inhibiting TNF but not L-DOPA-induced mechanical hyperalgesia. In conclusion, SLEE and fruticulin A display anti-inflammatory and analgesic properties. Therefore, fruticulin A is at least partially responsible for the activity observed in the ethanolic extract of Salvia lachnostachys.