Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2014 (2014), Article ID 841496, 5 pages
http://dx.doi.org/10.1155/2014/841496
Research Article

Protective Effect of Polysaccharides from Inonotus obliquus on Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats

1Department of Pharmaceutical Preparations, Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong 252000, China
2Department of Endocrinology, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, China

Received 17 May 2014; Accepted 15 June 2014; Published 30 June 2014

Academic Editor: Jianyou Guo

Copyright © 2014 Bao-zhong Diao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Vetrichelvan, M. Jegadeesan, and B. A. U. Devi, “Anti-diabetic activity of alcoholic extract of Celosia argentea LINN. seeds in rats,” Biological and Pharmaceutical Bulletin, vol. 25, no. 4, pp. 526–528, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. Y. O. Kim, H. W. Park, J. H. Kim, J. Y. Lee, S. H. Moon, and C. S. Shin, “Anti-cancer effect and structural characterization of endo-polysaccharide from cultivated mycelia of Inonotus obliquus,” Life Sciences, vol. 79, no. 1, pp. 72–80, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. S. P. Wasser, “Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides,” Applied Microbiology and Biotechnology, vol. 60, no. 3, pp. 258–274, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. O. Kim, S. B. Han, H. W. Lee et al., “Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus,” Life Sciences, vol. 77, no. 19, pp. 2438–2456, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. H.-Y. Xu, J.-E. Sun, Z.-M. Lu, X.-M. Zhang, W.-F. Dou, and Z.-H. Xu, “Beneficial effects of the ethanol extract from the dry matter of a culture broth of Inonotus obliquus in submerged culture on the antioxidant defence system and regeneration of pancreatic β-cells in experimental diabetes in mice,” Natural Product Research, vol. 24, no. 6, pp. 542–553, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. L. Ma, H. Chen, Y. Zhang, N. Zhang, and L. Fu, “Chemical modification and antioxidant activities of polysaccharide from mushroom Inonotus obliquus,” Carbohydrate Polymers, vol. 89, no. 2, pp. 371–378, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. X. Xu, Y. Wu, and H. Chen, “Comparative antioxidative characteristics of polysaccharide-enriched extracts from natural sclerotia and cultured mycelia in submerged fermentation of Inonotus obliquus,” Food Chemistry, vol. 127, no. 1, pp. 74–79, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Somogyi, É. Ruzicska, A. Blázovics, Á. Vér, K. Rosta, and M. Tóth, “Insulin treatment decreases the antioxidant defense mechanism in experimental diabetes,” Medical Science Monitor, vol. 11, no. 7, pp. BR206–BR211, 2005. View at Google Scholar · View at Scopus
  9. D. W. Laight, P. T. Gunnarsson, A. V. Kaw, E. E. Änggård, and M. J. Carrier, “Physiological microassay of plasma total antioxidant status in a model of endothelial dysfunction in the rat following experimental oxidant stress in vivo,” Environmental Toxicology and Pharmacology, vol. 7, no. 1, pp. 27–31, 1999. View at Publisher · View at Google Scholar · View at Scopus
  10. N. Rakieten, M. L. Rakieten, and M. R. Nadkarni, “Studies on the diabetogenic action of streptozotocin (NSC-37917),” Cancer Chemotherapy Reports, vol. 29, pp. 91–98, 1963. View at Google Scholar · View at Scopus
  11. V. Chen and C. D. Ianuzzo, “Dosage effects of streptozotocin on rat tissue enzyme activities and glycogen concentration,” Canadian Journal of Physiology and Pharmacology, vol. 60, no. 10, pp. 1251–1256, 1982. View at Publisher · View at Google Scholar · View at Scopus
  12. American Diabetes Association, “Diagnosis and classification of diabetes mellitus,” Diabetes Care, vol. 30, pp. S42–S47, 2007. View at Google Scholar
  13. L. Y. Zhao, Q. J. Lan, Z. C. Huang, L. J. Ouyang, and F. H. Zeng, “Antidiabetic effect of a newly identified component of Opuntia dillenii polysaccharides,” Phytomedicine, vol. 18, no. 8-9, pp. 661–668, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. M. W. Massing, C. A. Sueta, M. Chowdhury, D. P. Biggs, and R. J. Simpson Jr., “Lipid management among coronary artery disease patients with diabetes mellitus or advanced age,” The American Journal of Cardiology, vol. 87, no. 5, pp. 646–649, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. S. A. Metz, “Oxygenation products of archidonic acid: third messengers of insulin release,” Prostaglandins, vol. 27, pp. 147–151, 1984. View at Google Scholar
  16. A. R. Chaudry, M. Alam, M. Ahmad, F. Z. Khan, and N. Nomani, “Studies on medicinal herbs. II: effect of Colchicum luteum on biochemical parameters of rabbit serum,” Fitoterapia, vol. 64, no. 6, pp. 510–515, 1993. View at Google Scholar · View at Scopus
  17. M. Y. Donath and S. E. Shoelson, “Type 2 diabetes as an inflammatory disease,” Nature Reviews Immunology, vol. 11, no. 2, pp. 98–107, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Chawla, K. D. Nguyen, and Y. P. S. Goh, “Macrophage-mediated inflammation in metabolic disease,” Nature Reviews Immunology, vol. 11, no. 11, pp. 738–749, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Spranger, A. Kroke, M. Möhlig et al., “Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)—Potsdam study,” Diabetes, vol. 52, no. 3, pp. 812–817, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. G. S. Hotamisligil, P. Arner, J. F. Caro, R. L. Atkinson, and B. M. Spiegelman, “Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance,” Journal of Clinical Investigation, vol. 95, no. 5, pp. 2409–2415, 1995. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Cavelti-Weder, A. Babians-Brunner, C. Keller et al., “Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes,” Diabetes Care, vol. 35, no. 8, pp. 1654–1662, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. A. M. Preston, “Modification of streptozotocin-induced diabetes by protective agents,” Nutrition Research, vol. 5, no. 4, pp. 435–446, 1985. View at Publisher · View at Google Scholar · View at Scopus