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Evidence-Based Complementary and Alternative Medicine
Volume 2014 (2014), Article ID 867075, 13 pages
http://dx.doi.org/10.1155/2014/867075
Research Article

Free Radicals Scavenging Capacity, Antidiabetic and Antihypertensive Activities of Flavonoid-Rich Fractions from Leaves of Trichilia emetica and Opilia amentacea in an Animal Model of Type 2 Diabetes Mellitus

1Unit of Formation in Sciences Applied and Technological (UFR/SAT) and Institute of Sciences of the Environment and the Rural Development (ISEDR), Polytechnic University of Dédougou, Burkina Faso
2Laboratory of Biochemistry and Applied Chemistry, University of Ouagadougou, 09 P.O. Box 848, Ouagadougou 09, Burkina Faso
3Laboratory of Animal Physiology, UFR Bioscience, University of Felix Houphouet Boigny of Abidjan, 22 P.O. Box 582, Abidjan 22, Cote D’Ivoire
4Department of Plant Physiology and Ecology, Taras Shevchenko National University of Kyiv, Volodymyrs’ka Street 64, Kyiv 01601, Ukraine
5Laboratory of Plant Ecology and Biology, University of Ouagadougou, 09 P.O. Box 848, Ouagadougou 09, Burkina Faso
6Department of Plant Physiology, Slovak Agriculture University in Nitra, A. Hlinku 2, 94976 Nitra, Slovakia
7Laboratory of Tropical and Subtropical Agronomy and Ethnobotany, Department of Plants Production, Faculty of Biosciences Ingineering, Gent University, Belgium
8Institute of Genetics, University of Bucharest, 060101 Bucharest, Romania
9Laboratory of Biochemistry and Molecular Genetics Microbial, University of Ouagadougou, 03 P.O. Box 7131, Ouagadougou 03, Burkina Faso

Received 3 June 2013; Accepted 5 November 2013; Published 28 January 2014

Academic Editor: Mohamed Eddouks

Copyright © 2014 Kiessoun Konaté et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Trichilia emetica and Opilia amentacea traditional Burkinabe medicinal plants were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of type 2 diabetes. In vitro and in vivo antioxidant and antihypertensive potential and antilipidemia and antihyperglycemia activities in an animal model of type 2 diabetes mellitus have been studied. The antioxidant activity of the flavonoids from leaves of Trichilia emetica and Opilia amentacea has been evaluated using β-carotene-linoleic acid system, 1,1-diphenyl-2-picrylhydrazyl inhibitory activity, chelation of iron (II) ions, and lipid peroxidation which showed more pronounced antioxidant capacities of Trichilia emetica. Total cholesterol concentrations decreased in an animal model of type 2 diabetes mellitus under effects of flavonoid-rich fractions from leaves of Trichilia emetica and Opilia amentacea has been observed. Extract of flavonoid-rich fractions from Trichilia emetica shown maximum radical scavenging activity and possessed marked antiamylase activity which may be due to the presence of certain secondary metabolites. Suggested better antihyperglycemia, antilipidemia, and antihypertensive properties of flavonoid-rich fractions from Trichilia emetica compared to the extract of Opilia amentacea are demonstrating antidiabetic potential of Trichilia emetica as therapeutic targets for the management of type 2 diabetes.