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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 873607, 8 pages
Research Article

Evaluation of the Antihyperuricemic Activity of Phytochemicals from Davallia formosana by Enzyme Assay and Hyperuricemic Mice Model

1School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan
2Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 110, Taiwan
3Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 333, Taiwan
4National Research Institute of Chinese Medicine, Taipei 112, Taiwan
5Graduate Institute of Athletics and Coaching Science, National Taiwan Sport University, Taoyuan 333, Taiwan

Received 22 December 2013; Revised 10 March 2014; Accepted 13 March 2014; Published 4 May 2014

Academic Editor: Wen Chuan Lin

Copyright © 2014 Chen-Yu Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Abnormal serum urate levels are recognized as a critical factor in the progression of several chronic diseases. To evaluate the antihyperuricemic effect of Davallia formosana, the inhibitory activities of 15 isolated phytochemicals, including five novel compounds of 6,8-dihydroxychromone-7-C-β-d-glucopyranoside (1), 6,8,3′,4′-tetrahydroxyflavanone-7-C-β-d-glucopyranoside (2), 6,8,4′-trihydroxyflavanone-7-C-β-d-glucopyranoside (3), 8-(2-pyrrolidinone-5-yl)-catechin-3-O-β-d-allopyranoside (4), and epiphyllocoumarin-3-O-β-d-allopyranoside (5), were examined against xanthine oxidase (XOD) and in a potassium oxonate-(PTO-) induced acute hyperuricemic mice model. The results indicated that compounds 3 and 5 significantly inhibited XOD activity in vitro and reduced serum uric acid levels in vivo. This is the first report providing new insights into the antihyperuricemic activities of flavonoid glycosides which can possibly be developed into potential hypouricemic agents.