Ginsenosides Rb1 and Rg1 Stimulate Melanogenesis in Human Epidermal Melanocytes via PKA/CREB/MITF Signaling

Figure 3

Ginsenosides Rb1 and Rg1 triggered CREB signaling in melanocytes. Melanocytes were treated with Rb1 (100 μM), Rg1 (300 μM) for the indicated times, and the levels of phosphorylated CREB (p-CREB) were quantified and normalized to the level of β-actin by western blotting analysis (a). The normalized data for each was plotted as bar graphs (b). Data are expressed as the mean ± SD from three independent experiments that were carried out in triplicate. ^∗𝑃<0.05, ^∗∗𝑃<0.01, as compared with the control (as determined by one-way ANOVA). These experiments were conducted with melanocytes that were cultured from three different donors.

(a)

(b)