Xiao Yao San Improves Depressive-Like Behavior in Rats through Modulation of β-Arrestin 2-Mediated Pathways in Hippocampus

Table 1

MALDI-TOF MS identification of protein molecules with altered expression.

Number^a	Accession number^b	Molecular weight^c	𝑝I^c	Score^d	Protein name	Expression level^e
1	P67779/PHB_RAT	29859	5.57	57 (51)	Prohibitin	↑, ⇑
2	P28073/PSB6_RAT	25502	4.85	39 (26)	Proteasome subunit beta type-6	↑, ⇑
3	P68370/TBA1A_RAT	50788	4.94	64 (25)	Tubulin alpha-1A chain	↓, ⇓
4	N/A^f					↓, ⇓
5	N/A					↓, ⇓
6	Q4V8B2/DCNL3_RAT	34899	5.07	60 (51)	DCN1-like protein 3	↓, ⇓
7	P36876/2ABA_RAT	52159	5.82	55 (51)	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	↓, ⇓
8	Q6P9T8/TBB2C_RAT	50225	4.79	83 (26)	Tubulin beta-2C chain	↓, ⇓
9	N/A					↓, ⇓
10	Q8CJ99/SCLT1_RAT	80622	5.98	52 (51)	Sodium channel and clathrin linker 1	↓, ⇓

MALDI-TOF MS: matrix-assisted laser desorption/ionization time of flight mass spectrometer.
^adefined according to spot positions in 2DE gel indicated, as in Figure 4.
^bdefined from http://www.uniprot.org/.
^cMolecular weight value calculated by amino acid count; 𝑝I value calculated from the database entry without any processing.
^dProtein scores are derived from ions scores as a nonprobabilistic basis for ranking protein hits. Protein scores greater than threshold value are significant (𝑃<0.05).
^e↑↓ Expression of sham group compared to that of model group; ⇑⇓ expression of XYS group compared to that of model group.
^fNo effective peaks of peptide mass fingerprinting were available.