Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines

Figure 2

Evaluation in vivo of the effect of α-melittin nanoparticles on the inhibition of melanoma development. (a) Tumor volume over time showing that only the α-melittin nanoparticle group was significantly inhibited. (b) Comparative sizes and (c) volumes of the excised tumors between different groups after 13 days growth. Means ± SD, 𝑛=5, ^∗∗𝑃<0.01. Reprinted with permission from C. Huang, H. Jin, and Y. Qian et al., “Hybrid melittin cytolytic peptide-driven ultrasmall lipid nanoparticles block melanoma growth in vivo,” ACS Nano, volume 7, number 7, 5791-5800, 2013. (DOI: 10.1021/nn400683s). Copyright (2013) American Chemical Society.

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