Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 905639, 7 pages
http://dx.doi.org/10.1155/2014/905639
Research Article

Evaluation of the In Vitro Antiplasmodial, Antileishmanial, and Antitrypanosomal Activity of Medicinal Plants Used in Saudi and Yemeni Traditional Medicine

1Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
2Department of Pharmacognosy, Faculty of Pharmacy, Sana’a University, P.O. Box 33039, Sana’a, Yemen
3Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Universiteitsplein 1, 2610 Antwerp, Belgium

Received 28 January 2014; Accepted 30 April 2014; Published 21 May 2014

Academic Editor: José Luis Ríos

Copyright © 2014 Ramzi A. Mothana et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. M. Salem and K. A. Werbovetz, “Natural products from plants as drug candidates and lead compounds against leishmaniasis and trypanosomiasis,” Current Medicinal Chemistry, vol. 13, no. 21, pp. 2571–2598, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. World Health Organization (WHO), “Research priorities for chagas disease, human African trypanosomiasis and leishmaniasis,” Technical Report Series 975, WHO, Geneva, Switzerland, 2012. View at Google Scholar
  3. D. Ganesh, H. P. Fuehrer, P. Starzengrüber et al., “Antiplasmodial activity of flavonol quercetin and its analogues in Plasmodium falciparum: evidence from clinical isolates in Bangladesh and standardized parasite clones,” Parasitology Research, vol. 110, no. 6, pp. 2289–2295, 2012. View at Publisher · View at Google Scholar
  4. S. Hoet, F. Opperdoes, R. Brun, and J. Quetin-Leclercq, “Natural products active against African trypanosomes: a step towards new drugs,” Natural Product Reports, vol. 21, no. 3, pp. 353–364, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. A. S. Al-Dubai and A. A. Al-khulaidi, Medicinal and Aromatic Plants of Yemen (in Arabic), Obadi Center, Sana'a, Yemen, 1996.
  6. J. Fleurentin and J. M. Pelt, “Repertory of drugs and medicinal plants of Yemen,” Journal of Ethnopharmacology, vol. 6, no. 1, pp. 85–108, 1982. View at Google Scholar · View at Scopus
  7. A. Schopen, Traditionelle Heilmittel in Jemen, Franz Steiner, Berlin, Germany, 1983.
  8. P. Cos, A. J. Vlietinck, D. V. Berghe, and L. Maes, “Anti-infective potential of natural products: how to develop a stronger in vitro ‘proof-of-concept’,” Journal of Ethnopharmacology, vol. 106, no. 3, pp. 290–302, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. M. T. Makler, J. M. Ries, J. A. Williams et al., “Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity,” American Journal of Tropical Medicine and Hygiene, vol. 48, no. 6, pp. 739–741, 1993. View at Google Scholar · View at Scopus
  10. H. Hirumi and K. Hirumi, “Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers,” Journal of Parasitology, vol. 75, no. 6, pp. 985–989, 1989. View at Google Scholar · View at Scopus
  11. B. Raz, M. Iten, Y. Grether-Buhler, R. Kaminsky, and R. Brun, “The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T. b. rhodesiense, T. b. gambiense) in vitro,” Acta Tropica, vol. 68, no. 2, pp. 2592–2597, 1997. View at Google Scholar
  12. F. S. Buckner, C. L. Verlinde, A. C. La Flamme, and W. C. Van Voorhis, “Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase,” Antimicrobial Agents and Chemotherapy, vol. 40, no. 11, pp. 2592–2597, 1996. View at Google Scholar
  13. N. M. Al-Musayeib, R. A. Mothana, S. Al-Massarani, A. Matheeussen, P. Cos, and L. Maes, “Study of the in vitro antiplasmodial, antileishmanial and antitrypanosomal activities of medicinal plants from Saudi Arabia,” Molecules, vol. 17, no. 10, pp. 11379–11390, 2012. View at Publisher · View at Google Scholar
  14. E. Abdel-Sattar, F. M. Harraz, S. M. A. Al-ansari et al., “Acylated pregnane glycosides from Caralluma tuberculata and their antiparasitic activity,” Phytochemistry, vol. 69, no. 11, pp. 2180–2186, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Abdel-Sattar, F. M. Harraz, S. M. A. Al-Ansari et al., “Antiplasmodial and antitrypanosomal activity of plants from the Kingdom of Saudi Arabia,” Journal of Natural Medicines, vol. 63, no. 2, pp. 232–239, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. M. A. Alshawsh, R. A. Mothana, H. A. Al-Shamahy, S. F. Alsllami, and U. Lindequist, “Assessment of antimalarial activity against Plasmodium falciparum and phytochemical screening of some Yemeni medicinal plants,” Evidence Based Complementary and Alternative Medicine, vol. 6, no. 4, pp. 453–456, 2009. View at Publisher · View at Google Scholar
  17. G. Bradacs, L. Maes, and J. Heilmann, “In Vitro cytotoxic, antiprotozoal and antimicrobial activities of medicinal plants from Vanuatu,” Phytotherapy Research, vol. 24, no. 6, pp. 800–809, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. J. A. Udobang, P. A. Nwafor, and J. E. Okokon, “Analgesic and antimalarial activities of crude leaf extract and fractions of Acalypha wilkensiana,” Journal of Ethnopharmacology, vol. 127, no. 2, pp. 373–378, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. M. C. Navarro, M. P. Montilla, M. M. Cabo et al., “Antibacterial, antiprotozoal and antioxidant activity of five plants used in izabal for infectious diseases,” Phytotherapy Research, vol. 17, no. 4, pp. 325–329, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. E. O. Okanla, J. A. Owoyale, and J. A. Akinyanju, “Trypanocidal effect of an aqueous extract of Acalypha hispida leaves,” Journal of Ethnopharmacology, vol. 29, no. 2, pp. 233–237, 1990. View at Publisher · View at Google Scholar · View at Scopus
  21. E. Abdel-Sattar, N. G. Shehab, C. Ichino et al., “Antitrypanosomal activity of some pregnane glycosides isolated from Caralluma species,” Phytomedicine, vol. 16, no. 6-7, pp. 659–664, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. D. J. Hubert, N. Céline, N. Michel et al., “In Vitro leishmanicidal activity of some Cameroonian medicinal plants,” Experimental Parasitology, vol. 134, no. 3, pp. 304–308, 2013. View at Publisher · View at Google Scholar
  23. Y. Estevez, D. Castillo, M. T. Pisango et al., “Evaluation of the leishmanicidal activity of plants used by Peruvian Chayahuita ethnic group,” Journal of Ethnopharmacology, vol. 114, no. 2, pp. 254–259, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. V. C. Filho, C. Meyre-Silva, R. Niero et al., “Evaluation of antileishmanial activity of selected Brazilian plants and identification of the active principles,” Evidence Based Complementary and Alternative Medicine, vol. 2013, Article ID 265025, 7 pages, 2013. View at Publisher · View at Google Scholar
  25. M. Abreu Miranda, R. F. Tiossi, M. R. da Silva et al., “In Vitro leishmanicidal and cytotoxic activities of the glycoalkaloids from Solanum lycocarpum (Solanaceae) fruits,” Chemistry and Biodiversity, vol. 10, no. 4, pp. 642–648, 2013. View at Google Scholar
  26. M. Chinchilla, I. Valerio, R. Sánchez et al., “In Vitro antimalarial activity of extracts of some plants from a biological reserve in Costa Rica,” Revista de Biologia Tropical, vol. 60, no. 2, pp. 881–891, 2012. View at Google Scholar
  27. C. Kamaraj, N. K. Kaushik, D. Mohanakrishnan et al., “Antiplasmodial potential of medicinal plant extracts from Malaiyur and Javadhu hills of South India,” Parasitology Research, vol. 111, no. 2, pp. 703–715, 2012. View at Google Scholar
  28. G. Alvarez, A. Pabón, J. Carmona, and S. Blair, “Evaluation of clastogenic potential of the antimalarial plant Solanum nudum,” Phytotherapy Research, vol. 18, no. 10, pp. 845–848, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. N. Fokialakis, E. Kalpoutzakis, B. L. Tekwani et al., “Evaluation of the antimalarial and antileishmanial activity of plants from the Greek island of Crete,” Journal of Natural Medicines, vol. 61, no. 1, pp. 38–45, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. H. K. Manjili, H. Jafari, A. Ramazani, and N. Davoudi, “Anti-leishmanial and toxicity activities of some selected Iranian medicinal plants,” Parasitology Research, vol. 111, no. 5, pp. 2115–2121, 2012. View at Publisher · View at Google Scholar
  31. N. M. Al-Musayeib, R. A. Mothana, A. Matheeussen, P. Cos, and L. Maes, “In Vitro antiplasmodial, antileishmanial and antitrypanosomal activities of selected medicinal plants used in the traditional Arabian Peninsular region,” BMC Complementery and Alternative Medicine, vol. 12, p. 49, 2012. View at Publisher · View at Google Scholar
  32. A. Bagavan, A. A. Rahuman, C. Kamaraj, N. K. Kaushik, D. Mohanakrishnan, and D. Sahal, “Antiplasmodial activity of botanical extracts against Plasmodium falciparum,” Parasitology Research, vol. 108, no. 5, pp. 1099–1109, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. C. Kamaraj, N. K. Kaushik, A. A. Rahuman et al., “Antimalarial activities of medicinal plants traditionally used in the villages of Dharmapuri regions of South India,” Journal of Ethnopharmacology, vol. 141, no. 3, pp. 796–802, 2012. View at Publisher · View at Google Scholar
  34. V. K. Dua, G. Verma, D. D. Agarwal, M. Kaiser, and R. Brun, “Antiprotozoal activities of traditional medicinal plants from the Garhwal region of North West Himalaya, India,” Journal of Ethnopharmacology, vol. 136, no. 1, pp. 123–128, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. S. B. Ahmed, R. M. Sghaier, F. Guesmi et al., “Evaluation of antileishmanial, cytotoxic and antioxidant activities of essential oils extracted from plants issued from the leishmaniasis-endemic region of Sned (Tunisia),” Natural Product Research, vol. 25, no. 12, pp. 1195–1201, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. P. Escobar, S. M. Leal, L. V. Herrera, J. R. Martinez, and E. Stashenko, “Chemical composition and antiprotozoal activities of Colombian Lippia spp essential oils and their major components,” Memorias do Instituto Oswaldo Cruz, vol. 105, no. 2, pp. 184–190, 2010. View at Google Scholar · View at Scopus
  37. T. Moon, J. M. Wilkinson, and H. M. A. Cavanagh, “Antiparasitic activity of two Lavandula essential oils against Giardia duodenalis, Trichomonas vaginalis and Hexamita inflata,” Parasitology Research, vol. 99, no. 6, pp. 722–728, 2006. View at Publisher · View at Google Scholar · View at Scopus
  38. S. K. Sadhu, E. Okuyama, H. Fujimoto, and M. Ishibashi, “Diterpenes from Leucas aspera inhibiting prostaglandin-induced contractions,” Journal of Natural Products, vol. 69, no. 7, pp. 988–994, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. S. N. Das, V. J. Patro, and S. C. A. Dinda, “A review: ethnobotanical survey of genus Leucas,” Pharmacognosy Reviews, vol. 6, no. 12, pp. 100–106, 2012. View at Google Scholar
  40. F. Abe, T. Yamauchi, T. Nagao et al., “Ursolic acid as a trypanocidal constituent in rosemary,” Biological and Pharmaceutical Bulletin, vol. 25, no. 11, pp. 1485–1487, 2002. View at Publisher · View at Google Scholar · View at Scopus