Apoptosis Induction by the Total Flavonoids from Arachniodes exilis in HepG2 Cells through Reactive Oxygen Species-Mediated Mitochondrial Dysfunction Involving MAPK Activation
Figure 6
The effect of TFAE on the expression of apoptosis-related proteins in HepG2 cells by Western blot analysis (a) cytochrome c release from mitochondria into cytosol; (b) activation of caspase family members as well as modulation of Bcl-2 family members; (c) reduction of the ratio of Bcl-2/Bax, versus the control group; (d) TFAE-induced phosphorylation of MAPK pathway; (e) effect of NAC on TFAE-induced apoptosis and the phosphorylation of JNK and p38; (f) effects of SB203580 and SP600125 on the TFAE-induced apoptosis.
