Studies Diagnosis Intervention group Control group Outcomes Duration Chen 2005 [26 ] SCOPD/I~II Chinese herb decoction + WM WM Clinical symptom; pulmonary function; arterial blood gas; medical expense; kidney, liver, urine, and blood routine test; and safety examination 6 months
He 2010 [27 ] SCOPD/II~III Chinese herb decoction + WM WM Clinical symptom; pulmonary function; and SGRQ 3 months Ke 2010 [28 ] SCOPD/I~IV Chinese herb decoction + WM Placebo + WM
Clinical symptom; pulmonary function; SGRQ; 6MWD; BODE; kidney, liver, urine, and blood routine test; and safety examination 2 months Li 2006 [29 ] AECOPD/I~II Chinese herb decoction + WM WM Clinical symptom; pulmonary function; arterial blood gas; kidney, liver, urine, and blood routine test; TNF-
; and safety examination 10 days Li 2008 [30 ] SCOPD/I~II Bufei-Yishen-Huayu decoction + WM
WM Clinical symptom; pulmonary function; kidney, liver, urine, blood, and stool routine test; safety examination; TNF-
; and TGF-
2 weeks
Li et al. 2012 [11 ], Xie et al. 2013 [23 ], Li et al. 2012 [31 ], and Li et al. 2013 [32 ]
SCOPD/I~III
Bu-Fei Yi-Shen granule + Shu-Fei Tie ointment + WM Placebo + WM Frequency and duration of acute exacerbation of COPD; pulmonary function; quality of life; 6MWD; clinical symptom; and safety examination 4 months Liu 2010 [33 ] NA/NA Chinese herb decoction + WM Placebo + WM Clinical symptom; pulmonary function; SGRQ; and safety examination 1 month Luo 2007 [34 ] AECOPD/I~III Qinjin-Huatan decoction + WM WM Clinical symptom; pulmonary function; kidney, liver, urine, blood, and stool routine test; arterial blood gas; and safety examination 10 days Matthys et al. 2013 [35 ] SCOPD/II~III EPs 7630 (roots of Pelargonium sidoides ) + WM Placebo + WM Time to first exacerbation of COPD; number and duration of exacerbations; pulmonary function; SGRQ; Integrative Medicine Patient Satisfaction Scale; laboratory safety parameters; and sputum examination 6 months Murali et al. 2006 [36 ] SCOPD/II Herb (Bryonia alba , Cephaelis ipecacuanha, and Drosera peltata ) extraction + WM Placebo + WM Clinical symptom; pulmonary function; arterial blood gas; and safety observation 6 months Worth et al. 2009 [14 ] AECOPD/II~III Herb (Eucalyptole) extraction + WM Placebo + WM Frequency, duration, and severity of exacerbations; pulmonary function; clinical symptom; SGRQ; and safety examination 6 months Xiao 2008 [37 ] SCOPD/I~III
Chinese herb extraction + routine medication Theophylline + routine medication Clinical symptom; pulmonary function; and IL-10 and TNF-
in the peripheral blood 3 months Zeng 2010 [38 ] SCOPD/I~II Chinese herb decoction + WM Placebo + WM Frequency, duration, and severity of exacerbations; pulmonary function; clinical symptom; SGRQ; and safety examination 4 weeks Zhang et al. 2006 [39 ] AECOPD/NA Chinese herb injection + WM Placebo + WM Clinical symptom; pulmonary function; arterial blood gas; and safety observation 1 week
Zhao 2010 [40 ] SCOPD/II~IV Chinese herb decoction + WM WM Clinical symptom; BODE index; 6MWD; sTNF and iNOs; and safety observation 3 months
