Evidence-Based Complementary and Alternative Medicine / 2014 / Article / Tab 1

Review Article

A Systematic Review and Meta-Analysis of Herbal Medicine on Chronic Obstructive Pulmonary Diseases

Table 1

Characteristics of the included studies.

StudiesDiagnosisIntervention groupControl groupOutcomesDuration

Chen 2005 [26] SCOPD/I~IIChinese herb decoction + WMWMClinical symptom; pulmonary function; arterial blood gas; medical expense; kidney, liver, urine, and blood routine test; and safety examination6 months
He 2010 [27]SCOPD/II~IIIChinese herb decoction + WMWMClinical symptom; pulmonary function; and SGRQ3 months
Ke 2010 [28]SCOPD/I~IVChinese herb decoction + WMPlacebo + WM Clinical symptom; pulmonary function; SGRQ; 6MWD; BODE; kidney, liver, urine, and blood routine test; and safety examination2 months
Li 2006 [29]AECOPD/I~IIChinese herb decoction + WMWMClinical symptom; pulmonary function; arterial blood gas; kidney, liver, urine, and blood routine test; TNF- ; and safety examination10 days
Li 2008 [30]SCOPD/I~IIBufei-Yishen-Huayu decoction + WM WMClinical symptom; pulmonary function; kidney, liver, urine, blood, and stool routine test; safety examination; TNF- ; and TGF- 2 weeks
Li et al. 2012 [11], Xie et al. 2013 [23], Li et al. 2012 [31], and Li et al. 2013 [32] SCOPD/I~III Bu-Fei Yi-Shen granule + Shu-Fei Tie ointment + WMPlacebo + WMFrequency and duration of acute exacerbation of COPD; pulmonary function; quality of life; 6MWD; clinical symptom; and safety examination4 months
Liu 2010 [33]NA/NAChinese herb decoction + WMPlacebo + WMClinical symptom; pulmonary function; SGRQ; and safety examination1 month
Luo 2007 [34]AECOPD/I~IIIQinjin-Huatan decoction + WMWMClinical symptom; pulmonary function; kidney, liver, urine, blood, and stool routine test; arterial blood gas; and safety examination10 days
Matthys et al. 2013 [35]SCOPD/II~IIIEPs 7630 (roots of Pelargonium sidoides) + WMPlacebo + WMTime to first exacerbation of COPD; number and duration of exacerbations; pulmonary function; SGRQ; Integrative Medicine Patient Satisfaction Scale; laboratory safety parameters; and sputum examination6 months
Murali et al. 2006 [36]SCOPD/IIHerb (Bryonia alba, Cephaelis ipecacuanha, and  Drosera peltata) extraction + WMPlacebo + WMClinical symptom; pulmonary function; arterial blood gas; and safety observation6 months
Worth et al. 2009 [14]AECOPD/II~IIIHerb (Eucalyptole) extraction + WMPlacebo + WMFrequency, duration, and severity of exacerbations; pulmonary function; clinical symptom; SGRQ; and safety examination6 months
Xiao 2008 [37]SCOPD/I~III Chinese herb extraction + routine medicationTheophylline + routine medicationClinical symptom; pulmonary function; and IL-10 and TNF- in the peripheral blood3 months
Zeng 2010 [38]SCOPD/I~IIChinese herb decoction + WMPlacebo + WMFrequency, duration, and severity of exacerbations; pulmonary function; clinical symptom; SGRQ; and safety examination4 weeks
Zhang et al. 2006 [39]AECOPD/NAChinese herb injection + WMPlacebo + WMClinical symptom; pulmonary function; arterial blood gas; and safety observation1 week
Zhao 2010 [40]SCOPD/II~IVChinese herb decoction + WMWMClinical symptom; BODE index; 6MWD; sTNF and iNOs; and safety observation3 months

BODE: BMI, obstruction, dyspnea, and exercise; SGRQ: St. George’s Respiratory Questionnaire; WM: western medicine; 6MWD: six-minute walk distance.

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