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Evidence-Based Complementary and Alternative Medicine
Volume 2014 (2014), Article ID 951478, 8 pages
http://dx.doi.org/10.1155/2014/951478
Research Article

Effects of Stingless Bee Propolis on Experimental Asthma

1Laboratory of Immunophysiology, Department of Pathology, Biological and Health Sciences Center, Federal University of Maranhão (UFMA), 65085-580 São Luís, MA, Brazil
2Laboratory of Pharmacognosy, Department of Pharmacy, Biological and Health Sciences Center, Federal University of Maranhão (UFMA), 65085-580 São Luís, MA, Brazil

Received 27 December 2013; Revised 14 February 2014; Accepted 15 February 2014; Published 1 April 2014

Academic Editor: Vassya Bankova

Copyright © 2014 José Hidelbland Cavalcante de Farias et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Bee products have been used empirically for centuries, especially for the treatment of respiratory diseases. The present study evaluated the effect of treatment with a propolis hydroalcoholic extract (PHE) produced by Scaptotrigona aff. postica stingless bee in a murine asthma model. BALB/c mice were immunized twice with ovalbumin (OVA) subcutaneously. After 14 days, they were intranasally challenged with OVA. Groups P50 and P200 received PHE by gavage at doses of 50 and 200 mg/kg, respectively. The DEXA group was treated with intraperitoneal injection of dexamethasone. The OVA group received only water. The mice were treated daily for two weeks and then they were immunized a second time with intranasal OVA. The treatment with PHE decreased the cell number in the bronchoalveolar fluid (BAL). Histological analysis showed reduced peribronchovascular inflammation after treatment with PHE especially the infiltration of polymorphonuclear cells. In addition, the concentration of interferon-γ (IFN-γ) in the serum was decreased. These results were similar to those obtained with dexamethasone. Treatment with S. aff postica propolis reduced the pathology associated with murine asthma due an inhibition of inflammatory cells migration to the alveolar space and the systemic progression of the allergic inflammation.