Hepatoprotective Effect of Pretreatment with Thymus vulgaris Essential Oil in Experimental Model of Acetaminophen-Induced Injury

Table 1

The effect of Thymus essential oil on biomarkers of hepatic damage.

Groups and designe of treatment	ALT	AST	ALP	MPO
	(IU L^−1)
Group I, control, Tween 80	48.88 ± 2.05	113.3 ± 15.39	138.40 ± 10.67	0.058 ± 0.009
Group II, APAP control (250 mg kg^−1)	11130 ± 973.40^a	6860 ± 140.00^a	181.90 ± 24.75^a	0.251 ± 0.149ª
Group III, 125 mg kg^−1 of TEO + APAP	3847 ± 3673	3201 ± 2731	110.40 ± 35.74	0.101 ± 0.008
Group IV, 250 mg kg^−1 of TEO + APAP	261.10 ± 84.41^b	176.0 ± 76.50^b	71.37 ± 11.49^b	0.073 ± 0.009^b
Group V, 500 mg kg^−1 of TEO + APAP	110.70 ± 35.79^b	110.8 ± 22.53^b	79.20 ± 1.591^b	0.069 ± 0.009^b
Group VI, 200 mg kg^−1 of SLM + APAP	388.80 ± 148.10^b	286.7 ± 150.40^b	101.40 ± 40.01^b	0.091 ± 0.003^b

Values are mean ± SEM. 5 mice in each group (𝑛=5), 𝑃<0.05 values are considered statistically significant. ^a𝑃<0.05 acetaminophen (APAP) treated group compared with animals in control groups. ^b𝑃<0.05 mice treated with the Thyme essential oil (TEO) or Silymarin (SLM) compared with acetaminophen group.