Evidence-Based Complementary and Alternative Medicine / 2014 / Article / Tab 1

Review Article

Aspirin Resistance and Promoting Blood Circulation and Removing Blood Stasis: Current Situation and Prospectives

Table 1

Causes of aspirin resistance and potential strategies to overcome resistance.

Cause of ARStrategy to overcome AR

Noncompliance of patientsPatient education
Minimisation of adverse effects
Insufficient dosingBiofeedback use of platelet function assays and measurement of aspirin metabolites to guide increased dosing levels
Drug-drug interactionsCaution/avoid use of NSAIDs
Caution/avoid use of proton pump inhibitors
Non-COX-1-mediated TXA2 productionDuel or increased dose of antiplatelet therapy
Development of thromboxane receptor antagonists
Other pathways of platelet activationUse of drugs to inhibit final common pathways of platelet aggregation
Pharmacogenetic factorsExploitation of genetic polymorphisms-personalised antiplatelet therapy

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