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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 956924, 11 pages
http://dx.doi.org/10.1155/2014/956924
Research Article

Suxiao Jiuxin Pill Induces Potent Relaxation and Inhibition on Contraction in Human Artery and the Mechanism

1TEDA International Cardiovascular Hospital & The Affiliated Hospital of Hangzhou Normal University, Tianjin & Hangzhou, China
2Tianjin Zhongxin Pharmaceutical Group Co., Ltd. No. 6, Traditional Chinese Medicine Factory, Tianjin, China
3The Chinese University of Hong Kong, Hong Kong
4TEDA International Cardiovascular Hospital, Tianjin, China
5TEDA School of Biological Sciences and Biotechnology, Nankai University, Tianjin, China
6Department of Surgery, Oregon Health and Science University, Portland, OR, USA

Received 13 August 2013; Accepted 11 February 2014; Published 7 April 2014

Academic Editor: Hong Zhang

Copyright © 2014 Xiao-Yan Bai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Suxiao Jiuxin Pill, a compound Chinese traditional medicine with main components of tetramethylpyrazine and borneol, is widely used for antiangina treatment in China but its pharmacological effect on human blood vessels is unknown. We investigated the effect and possible mechanism of SJP in the human internal mammary artery (IMA, ) taken from patients undergoing coronary surgery. SJP caused full relaxation in KCl- (%, ) and U46619- (%, ) contracted IMA. Pretreatment of IMA with plasma concentrations of SJP (1 mg/mL), calculated from the plasma concentration of its major component borneol, significantly depressed the maximal contraction to KCl (from  mN to  mN, ) and U46619 (from  mN to  mN, ) while SJP at 10 mg/mL abolished the subsequent contraction. Endothelium denudation and inhibition of eNOS significantly altered the SJP-induced relaxation without changes of eNOS expression. We conclude that SJP has a potent inhibitory effect on the vasoconstriction mediated by a variety of vasoconstrictors in human arteries. The vasorelaxation involves both endothelium-dependent and -independent mechanisms. Thus, the effect of SJP on human arteries demonstrated in this study may prove to be particularly important in vasorelaxing therapy in cardiovascular disease.