Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2014 (2014), Article ID 956924, 11 pages
http://dx.doi.org/10.1155/2014/956924
Research Article

Suxiao Jiuxin Pill Induces Potent Relaxation and Inhibition on Contraction in Human Artery and the Mechanism

1TEDA International Cardiovascular Hospital & The Affiliated Hospital of Hangzhou Normal University, Tianjin & Hangzhou, China
2Tianjin Zhongxin Pharmaceutical Group Co., Ltd. No. 6, Traditional Chinese Medicine Factory, Tianjin, China
3The Chinese University of Hong Kong, Hong Kong
4TEDA International Cardiovascular Hospital, Tianjin, China
5TEDA School of Biological Sciences and Biotechnology, Nankai University, Tianjin, China
6Department of Surgery, Oregon Health and Science University, Portland, OR, USA

Received 13 August 2013; Accepted 11 February 2014; Published 7 April 2014

Academic Editor: Hong Zhang

Copyright © 2014 Xiao-Yan Bai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. L. Daviglus, D. M. Lloyd-Jones, and A. Pirzada, “Preventing cardiovascular disease in the 21st century: therapeutic and preventive implications of current evidence,” The American Journal of Cardiovascular Drugs, vol. 6, no. 2, pp. 87–101, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. E. G. Nabel and E. Braunwald, “A tale of coronary artery disease and myocardial infarction,” The New England Journal of Medicine, vol. 366, no. 1, pp. 54–63, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. S. R. Sun, X. Huang, and L. Zhang, “Advances in studies on pharmacokinetics, pharmacodynamics and clinical research of Suxiao Jiuxin Wan,” Chinese Traditional and Herbal Drugs, vol. 33, pp. 89–91, 2002. View at Google Scholar
  4. X. Duan, L. Zhou, T. Wu et al., “Chinese herbal medicine Suxiao Jiuxin wan for angina pectoris,” Cochrane Database of Systematic Reviews, no. 1, Article ID CD004473, 2008. View at Google Scholar · View at Scopus
  5. L. Feng, T. Han, and Y. L. Zhou, “. The conclusion of the clinic effect for Suxiao Jiuxin Wan for CHD and angina pectoris -,” Journal of Emergency Syndromes in Chinese Medicine, vol. 9, pp. 4–6, 2000. View at Google Scholar
  6. C. S. Li, Z. Q. Qu, S. S. Wang et al., “Effects of Suxiao Jiuxin Pill on oxidative stress and inflammatory response in rats with experimental atherosclerosis,” Journal of Traditional Chinese Medicine, vol. 31, no. 2, pp. 107–111, 2011. View at Google Scholar · View at Scopus
  7. G. Yuan, “Curative effect observions on Suxiao Jiuxin Wan compared to Xiao xin tong for Angina pectoris,” Medical Journal of Healing of Heart and Vessel, vol. 9, pp. 71–72, 2002. View at Google Scholar
  8. J. Wei and Y. Tang, “Comparing research on the clinical effect of Suxiao Jiuxin Wan for ischemic heart disease,” Journal of Emergency Syndromes in Chinese Medicine, vol. 164, pp. 159–160, 1995. View at Google Scholar
  9. L. L. Yang, Y. S. Yuan, Y. L. Tong, and C. Y. Guo, “Determination of tetramethylpyrazine and borneol in human plasma by GC-MSD,” Yao Xue Xue Bao, vol. 29, no. 9, pp. 697–701, 1994 (Chinese). View at Google Scholar · View at Scopus
  10. S. F. Dong and Z. G. Zhu, “Determination of the Contents of Ca, Mg, Fe, Cu and Zn in Suxiao Jiuxin Pill and the Analysis of Ca/Mg and Cu/Zn Values,” Guang Pu Xue Yu Guang Pu Fen Xi, vol. 22, no. 3, pp. x23–479, 2002 (Chinese). View at Google Scholar · View at Scopus
  11. State Administration of Traditional Chinese Medicine (SATCM) of the P.R. of China: Zhong Hua Ben Cao, Volume V:15, pp. 976–984. Shanghai Science & Technology Press, 2007.
  12. K. K. Hintz and J. Ren, “Tetramethylpyrazine elicits disparate responses in cardiac contraction and intracellular Ca2+ transients in isolated adult rat ventricular myocytes,” Vascular Pharmacology, vol. 40, no. 4, pp. 213–217, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Feng, Y. Xiong, F. Cheng, L. Zhang, S. Li, and Y. Li, “Effect of ligustrazine on ischemia-reperfusion injury in murine kidney,” Transplantation Proceedings, vol. 36, no. 7, pp. 1949–1951, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. L. B. Esberg and J. Ren, “The oxygen radical generator pyrogallol impairs cardiomyocyte contractile function via a superoxide and p38 MAP kinase-dependent pathway: protection by anisodamine, tetramethylpyrazine,” Cardiovascular Toxicology, vol. 4, no. 4, pp. 375–384, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. Z. Zhang, T. Wei, J. Hou, G. Li, S. Yu, and W. Xin, “Iron-induced oxidative damage and apoptosis in cerebellar granule cells: attenuation by tetramethylpyrazine and ferulic acid,” European Journal of Pharmacology, vol. 467, no. 1–3, pp. 41–47, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. S. Fu, Y. Y. Lin, S. C. Chou et al., “Tetramethylpyrazine inhibits activities of glioma cells and glutamate neuro-excitotoxicity: potential therapeutic application for treatment of gliomas,” Neuro-Oncology, vol. 10, no. 2, pp. 139–152, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. H. Shih, S. L. Wu, W. F. Chiou, H. H. Ku, T. L. Ko, and Y. S. Fu, “Protective effects of tetramethylpyrazine on kainate induced excitotoxicity in hippocampal culture,” Neuroreport, vol. 13, no. 4, pp. 515–519, 2002. View at Google Scholar · View at Scopus
  18. S. L. Liao, T. K. Kao, W. Y. Chen et al., “Tetramethylpyrazine reduces ischemic brain injury in rats,” Neuroscience Letters, vol. 372, no. 1-2, pp. 40–45, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. K. C. Wong, K. S. Ong, and C. L. Lim, “Composition of the Essential Oil of Rhizomes of Kaempferia galanga L,” Flavour and Fragrance Journal, vol. 7, no. 5, pp. 263–266, 1992. View at Publisher · View at Google Scholar · View at Scopus
  20. X. W. Li, J. Li, and H. der Werff, ‘Cinnamomum camphora’. Flora of China. Missouri Botanical Garden, St. Louis, Mo, USA & Harvard University Herbaria, Cambridge, Mass, USA, 2013.
  21. H. Song, T. Guo, R. Zhang et al., “Preparation of the traditional Chinese medicine compound recipe heart-protecting musk pH-dependent gradient-release pellets,” Drug Development and Industrial Pharmacy, vol. 28, no. 10, pp. 1261–1273, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. G. W. He and C. Q. Yang, “Comparison among arterial grafts and coronary artery: an attempt at functional classification,” Journal of Thoracic and Cardiovascular Surgery, vol. 109, no. 4, pp. 707–715, 1995. View at Publisher · View at Google Scholar · View at Scopus
  23. G. W. He, “Arterial grafts for coronary artery bypass grafting: biological characteristics, functional classification, and clinical choice,” Annals of Thoracic Surgery, vol. 67, no. 1, pp. 277–284, 1999. View at Publisher · View at Google Scholar · View at Scopus
  24. B. W. Lytle, E. H. Blackstone, J. F. Sabik, P. Houghtaling, F. D. Loop, and D. M. Cosgrove, “The effect of bilateral internal thoracic artery grafting on survival during 20 postoperative years,” Annals of Thoracic Surgery, vol. 78, no. 6, pp. 2005–2014, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. D. P. Taggart, R. D'Amico, and D. G. Altman, “Effect of arterial revascularisation on survival: a systematic review of studies comparing bilateral and single internal mammary arteries,” The Lancet, vol. 358, no. 9285, pp. 870–875, 2001. View at Publisher · View at Google Scholar · View at Scopus
  26. M. C. Sarabu, J. A. McClung, A. Fass, and G. E. Reed, “Early postoperative spasm in left internal mammary artery bypass grafts,” Annals of Thoracic Surgery, vol. 44, no. 2, pp. 199–200, 1987. View at Google Scholar · View at Scopus
  27. P. R. Vogt, O. Hess, and M. I. Turina, “Internal mammary artery spasm immediately after grafting to the left anterior descending artery: diagnosis and treatment,” European Heart Journal, vol. 17, no. 5, p. 804, 1996. View at Google Scholar · View at Scopus
  28. G. W. Stone and G. O. Hartzler, “Spontaneous reversible spasm in an internal mammary artery graft causing acute myocardial infarction,” The American Journal of Cardiology, vol. 64, no. 12, pp. 822–823, 1989. View at Google Scholar · View at Scopus
  29. G. W. He, F. L. Rosenfeldt, B. F. Buxton, and J. A. Angus, “Reactivity of human isolated internal mammary artery to constrictor and dilator agents: implications for treatment of internal mammary artery spasm,” Circulation, vol. 80, no. 3, pp. I141–I150, 1989. View at Google Scholar · View at Scopus
  30. H. Tatar, S. Cicek, H. Suer, A. T. Yilmaz, O. Y. Ozturk, and R. D. Narbay, “Use of topical sodium nitroprusside to relieve perioperative spasm of the internal mammary artery: a word of caution,” Journal of Thoracic and Cardiovascular Surgery, vol. 108, no. 2, p. 387, 1994. View at Google Scholar · View at Scopus
  31. D. Zabeeda, B. Medalion, S. Jackobshvilli, S. Ezra, A. Schachner, and A. J. Cohen, “Comparison of systemic vasodilators: effects on flow in internal mammary and radial arteries,” Annals of Thoracic Surgery, vol. 71, no. 1, pp. 138–141, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Novaković, L. Gojković-Bukarica, B. Beleslin-Cokić et al., “Differential antivasoconstrictor effects of levcromakalim and rilmakalim on the isolated human mammary artery and saphenous vein,” Journal of Pharmacological Sciences, vol. 92, pp. 108–114, 2003. View at Google Scholar
  33. L. H. Sanders and M. A. Newman, “Intractable postoperative internal thoracic artery spasm managed with angiographic intraluminal papaverine,” Journal of Thoracic and Cardiovascular Surgery, vol. 130, no. 3, pp. 938–940, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. R. E. Harskamp, J. D. McNeil, M. W. van Ginkel, R. B. Bastos, C. E. Baisden, and J. H. Calhoon, “Postoperative internal thoracic artery spasm after coronary artery bypass grafting,” Annals of Thoracic Surgery, vol. 85, no. 2, pp. 647–649, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. G. W. He, “Verapamil plus nitroglycerin solution maximally preserves endothelial function of the radial artery: comparison with papaverine solution,” Journal of Thoracic and Cardiovascular Surgery, vol. 115, no. 6, pp. 1321–1327, 1998. View at Publisher · View at Google Scholar · View at Scopus
  36. Z. W. Chen, Y. Huang, Q. Yang, X. Li, W. Wei, and G. W. He, “Urocortin-induced relaxation in the human internal mammary artery,” Cardiovascular Research, vol. 65, no. 4, pp. 913–920, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. Z. W. Chen, Q. Yang, Y. Huang, L. Fan, X. W. Li, and G. W. He, “Human urotensin II in internal mammary and radial arteries of patients undergoing coronary surgery,” Vascular Pharmacology, vol. 52, no. 1-2, pp. 70–76, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. G. W. He and Z. G. Liu, “Comparison of nitric oxide release and endothelium-derived hyperpolarizing factor-mediated hyperpolarization between human radial and internal mammary arteries,” Circulation, vol. 104, no. 1, pp. I344–I349, 2001. View at Google Scholar · View at Scopus
  39. G. W. He, J. A. Angus, and F. L. Rosenfeldt, “Reactivity of the canine isolated internal mammary artery, saphenous vein, and coronary artery to constrictor and dilator substances: Relevance to coronary bypass graft surgery,” Journal of Cardiovascular Pharmacology, vol. 12, no. 1, pp. 12–22, 1988. View at Google Scholar · View at Scopus
  40. X. Y. Bai, X. C. Liu, Q. Yang, X. D. Tang, and G. W. He, “The interaction between human urotensin II and vasodilator agents in human internal mammary artery with possible clinical implications,” Annals of Thoracic Surgery, vol. 92, no. 2, pp. 610–616, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. H. Wu, J. Guo, X. H. Li, and X. Huang, “Determination of Borneol in Blood After Keeping Suxiao Jiuxin Pills in Healthy People's Mouth by GC,” China Pharmacy, vol. 14, pp. 414–415, 2003. View at Google Scholar
  42. J. Guo, X. Huang, L. L. Wang, H. Meng, L. Zhang, and P. Ren, “Synchro-determ ination of borneol and tetramethylpyrazine in plasma by GC-FID for volunteers administrated with Suxiao Jiuxin Wan,” Chinese Traditional and Herbal Drugs, vol. 34, pp. 730–732, 2003. View at Google Scholar
  43. X. Y. Bai, X. C. Liu, W. B. Jing, Q. Yang, X. D. Tang, and G. W. He, “Effect of amlodipine in human internal mammary artery and clinical implications,” Annals of Thoracic Surgery, vol. 90, no. 6, pp. 1952–1957, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. G. Gao, X. Y. Bai, C. Xuan et al., “Role of TRPC3 channel in human internal mammary artery,” Archives of Medical Research, vol. 43, pp. 431–437, 2012. View at Google Scholar
  45. H. M. Xue, G. W. He, J. H. Huang, and Q. Yang, “New strategy of endothelial protection in cardiac surgery: Use of enhancer of endothelial nitric oxide synthase,” World Journal of Surgery, vol. 34, no. 7, pp. 1461–1469, 2010. View at Publisher · View at Google Scholar · View at Scopus
  46. Q. Yang, H. M. Xue, W. T. Wong et al., “AVE3085, an enhancer of endothelial nitric oxide synthase, restores endothelial function and reduces blood pressure in spontaneously hypertensive rats,” British Journal of Pharmacology, vol. 163, no. 5, pp. 1078–1085, 2011. View at Publisher · View at Google Scholar · View at Scopus
  47. S. Wang, “The Study on Pharmacological and Clinical Research of Suxiao Jiuxin Wan,” Zhongguo Lin Chuang Yi Yao Yan Jiu Za Zhi, vol. 178, pp. 42–45, 2007. View at Google Scholar
  48. S. F. Liu, Y. N. Cai, T. W. Evans, D. G. McCormack, G. R. Barer, and P. J. Barnes, “Ligustrazine is a vasodilator of human pulmonary and bronchial arteries,” European Journal of Pharmacology, vol. 191, no. 3, pp. 345–350, 1990. View at Publisher · View at Google Scholar · View at Scopus
  49. S. Li, P. Huang, and C. Liu, “Effect of ligustrazine injection on vascular endothelial cell of the patients with arteriosclerosis obliterans,” Zhongguo Zhong Xi Yi Jie He Za Zhi, vol. 20, no. 6, pp. 412–414, 2000. View at Google Scholar · View at Scopus
  50. Z. Q. Chen, L. Hong, and H. Wang, “Effect of tetramethylpyrazine on platelet activation and vascular endothelial function in patients with acute coronary syndrome undergoing percutaneous coronary intervention,” Zhongguo Zhong Xi Yi Jie He Za Zhi, vol. 27, no. 12, pp. 1078–1081, 2007. View at Google Scholar · View at Scopus
  51. Y. Ou, X. L. Guo, L. Zhai, X. Y. Liu, and Y. N. Cheng, “TMPDP, a tetramethylpyrazine derivative, protects vascular endothelial cells from oxidation damage by hydrogen peroxide,” Pharmazie, vol. 65, no. 10, pp. 755–759, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. J. R. Sheu, Y. C. Kan, W. C. Hung, C. H. Lin, and M. H. Yen, “The antiplatelet activity of tetramethylpyrazine is mediated through activation of NO synthase,” Life Sciences, vol. 67, no. 8, pp. 937–947, 2000. View at Publisher · View at Google Scholar · View at Scopus
  53. C. C. Tsai, T. Y. Lai, W. C. Huang, I. M. Liu, and J. T. Cheng, “Inhibitory effects of potassium channel blockers on tetramethylpyrazine-induced relaxation of rat aortic strip in vitro,” Life Sciences, vol. 71, no. 11, pp. 1321–1330, 2002. View at Publisher · View at Google Scholar · View at Scopus
  54. X. Li, L. Wu, X. Fan et al., “Network pharmacology study on major active compounds of Fufang Danshen formula,” Zhongguo Zhongyao Zazhi, vol. 36, no. 21, pp. 2911–2915, 2011. View at Publisher · View at Google Scholar · View at Scopus
  55. X. H. Chen, Z. Z. Lin, A. M. Liu et al., “The orally combined neuroprotective effects of sodium ferulate and borneol against transient global ischaemia in C57 BL/6J mice,” Journal of Pharmacy and Pharmacology, vol. 62, no. 7, pp. 915–923, 2010. View at Publisher · View at Google Scholar · View at Scopus
  56. Y. D. Liu, H. J. Sun, R. Li, W. Wu, and H. G. Chen, “Influence of borneol on nasal absorption of Ligustrazinee,” Zhongguo Zhongyao Zazhi, vol. 33, no. 3, pp. 259–261, 2008. View at Google Scholar · View at Scopus
  57. T. B. Bolton, “Mechanisms of action of transmitters and other substances on smooth muscle,” Physiological Reviews, vol. 59, no. 3, pp. 606–718, 1979. View at Google Scholar · View at Scopus
  58. S. B. Kribbs, W. M. Merritt, M. J. Clair et al., “Amlodipine monotherapy, angiotensin-converting enzyme inhibition, and combination therapy with pacing-induced heart failure,” Hypertension, vol. 31, no. 3, pp. 755–765, 1998. View at Google Scholar · View at Scopus
  59. X. L. Wang, Y. M. Liu, and G. J. Zhu, “Effects of Suxiao Jiuxin pill on patients with acute coronary syndrome undergoing early percutaneous coronary intervention,” Zhongguo Zhong Xi Yi Jie He Za Zhi, vol. 32, pp. 1483–1487, 2012 (Chinese). View at Google Scholar