Comparison of the Inhibitory Potential of Bavachalcone and Corylin against UDP-Glucuronosyltransferases
Figure 4
Determination of inhibition kinetic type and parameters (Ki) of UGT1A7 inhibited by bavachalcone. (a) Bavachalcone exhibits dose-dependent inhibition towards UGT1A7-catalyzed 4-MU glucuronidation. (b) Dixon plot of inhibitory effects of bavachalcone towards recombinant UGT1A7-catalyzed 4-MU glucuronidation. (c) Lineweaver-Burk plot of inhibitory effects of bavachalcone towards recombinant UGT1A7-catalyzed 4-MU glucuronidation. (d) Second plot of slopes from Lineweaver-Burk plot versus bavachalcone concentrations. Every data point represents the mean of two replicates.
