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Evidence-Based Complementary and Alternative Medicine
Volume 2014 (2014), Article ID 960258, 10 pages
Review Article

A Systematic Review for Anti-Inflammatory Property of Clusiaceae Family: A Preclinical Approach

1Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil
2Department of Pharmacy, Federal University of Sergipe, São Cristóvão, SE, Brazil
3Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil
4Department of Chemistry, Federal University of Sergipe, São Cristóvão, SE, Brazil
5School of Nursing and Pharmacy, Federal University of Alagoas, Maceió, AL, Brazil
6Laboratory of Pre-Clinical Pharmacology (LAPEC), Department of Physiology, Federal University of Sergipe (UFS), São Cristóvão, SE, Brazil

Received 29 January 2014; Revised 23 April 2014; Accepted 24 April 2014; Published 26 May 2014

Academic Editor: Juliano Ferreira

Copyright © 2014 Mônica Santos de Melo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Clusiaceae family (sensu lato) is extensively used in ethnomedicine for treating a number of disease conditions which include cancer, inflammation, and infection. The aim of this review is to report the pharmacological potential of plants of Clusiaceae family with the anti-inflammatory activity in animal experiments. Methods. A systematic review about experiments investigating anti-inflammatory activity of Clusiaceae family was carried out by searching bibliographic databases such as Medline, Scopus and Embase. In this update, the search terms were “anti-inflammatory agents,” “Clusiaceae,” and “animals, laboratory.” Results. A total of 255 publications with plants this family were identified. From the initial 255 studies, a total of 21 studies were selected for the final analysis. Studies with genera Allanblackia, Clusia, Garcinia or Rheedia, and Hypericum showed significant anti-inflammatory activity. The findings include a decrease of total leukocytes, a number of neutrophils, total protein concentration, granuloma formation, and paw or ear edema formation. Other interesting findings included decreased of the MPO activity, and inflammatory mediators such as NF-κB and iNOS expression, PGE2 and Il-1β levels and a decrease in chronic inflammation. Conclusion. The data reported suggests the anti-inflammatory effect potential of Clusiaceae family in animal experiments.