Identification of a Predictive Biomarker for the Beneficial Effect of Keishibukuryogan, a Kampo (Japanese Traditional) Medicine, on Patients with Climacteric Syndrome

Table 2

Clinical characteristics of 34 patients who finished the KBG treatment, classified by their CA repeat polymorphism of the ERβ gene.

	SS	SL	LL	𝑃
	𝑛=9	𝑛=12	𝑛=13
Age	50.1±2.37	51.2±5.29	47.5±4.86	0.100
Height (cm)	157.1±3.78	155.6±3.22	157.7±3.39	0.502
Body weight (kg)	54.0±8.26	53.3±6.26	51.2±6.07	0.913
BMI (kg/cm^2)	22.0±4.18	22.1±3.21	20.6±2.43	0.747
Age of menarche	12.6±1.33	12.3±1.07	12.5±1.13	0.901
SDS	46.8±10.29	46.0±9.05	45.9±7.30	0.971
KI	25.0±5.12	28.4±6.49	29.2±7.85	0.341
Hysterectomized	0	1	1
Ratio of menopause (%); (delited hysterectomized)	33.3	66.7	30.8

Data are mean ± SD. S: short allele, L: long allele, SDS: self-rating depression scale, and KI: Kupperman index. 𝑃 values (SS versus SL versus LL) were obtained by Kruskal-Wallis test or 1-way ANOVA.