Screening to Identify Commonly Used Chinese Herbs That Affect ERBB2 and ESR1 Gene Expression Using the Human Breast Cancer MCF-7 Cell Line
Table 2
Effects of commonly used Chinese herbs on cytotoxicity.
Scientific name
Dose range
Cell survival 80%
Qi-supplying
Astragalus membranaceus
0.1~10 μg/mL
(—)
Atractylodes macrocephala
0.1~10 μg/mL
(—)
Poria cocos
0.1~10 μg/mL
(—)
Glycyrrhiza uralensis
0.1~10 μg/mL
(—)
Agastache rugosa
0.1~10 μg/mL
(—)
Codonopsis pilosula
0.1~10 μg/mL
(—)
Zingiber officinale
0.1~10 μg/mL
(—)
Blood-regulating
Angelica sinensis
0.1~10 μg/mL
3 μg/mL*
Ligusticum chuanxiong
0.1~10 μg/mL
(—)
Ziziphus jujuba
0.1~10 μg/mL
(—)
Millettia dielsiana
0.1~10 μg/mL
(—)
Curcuma phaeocaulis
0.1~10 μg/mL
(—)
Heat-clearing
Folium nelumbinis
0.1~10 μg/mL
(—)
Bupleurum chinense
0.1~10 μg/mL
(—)
Mentha piperita
0.1~10 μg/mL
(—)
Gardenia jasminoides
0.1~10 μg/mL
(—)
Paeonia suffruticosa
0.1~10 μg/mL
(—)
Taraxacum mongolicum
0.1~10 μg/mL
(—)
Anemarrhena asphodeloides
0.1~10 μg/mL
(—)
Yin-nourishing
Paeonia lactiflora
0.1~10 μg/mL
10 μg/mL*
Rehmannia glutinosa
0.1~10 μg/mL
(—)
Ligustrum lucidum
0.1~10 μg/mL
(—)
Compound recipes and abbreviations
Si-Wu-Tang
0.1~10 μg/mL
(—)
Jia-Wei-Xiao-Yao-San
0.1~10 μg/mL
(—)
Suan-Zsao-Ren-Tang
0.1~10 μg/mL
(—)
Reduced formula of Suan-Zsao-Ren-Tang
0.1~10 μg/mL
(—)
K’uan-Hsin-Yin
0.1~10 μg/mL
(—)
VGH-S4
0.1~10 μg/mL
(—)
Cell cytotoxicity was determined by MTT assay as described in the Methods section. VGH-S4 is a compound recipe commonly used in Taipei Veterans General Hospital.
*
versus vehicle group ( ≥ 4~6).
