Evaluation of Traditional Medicines for Neurodegenerative Diseases Using Drosophila Models

Figure 1

Representative neurological phenotypes of the Drosophila neurodegenerative disease models. elav-GAL4, GMR-GAL4, and TH-GAL4 are drivers that regulate gene expression in neurons, developing eyes, and DA neurons, respectively. elav > Aβ42 and GMR > Aβ42 represent flies expressing Aβ42 in the neurons and developing eyes, respectively. TH > GFP represents flies expressing GFP in the DA neurons. GFP: green fluorescent protein; GMR: glass multimer reporter; NDD: neurodegenerative disease; TH: tyrosine hydroxylase; UAS: upstream activation sequence.