Table 2: Genes associated with Toll-like receptor signaling pathway.

SymbolGenBank accessionGene descriptionlog2 FCa
M/NSH/MSM/MSL/MOseltamivir/M

Tlr7 mMC009252Toll-like receptor 7, TLR71.390.02−2.02−0.43−0.92
MyD88 PH_mM_0009196Myeloid differentiation primary response gene 882.22−1.18−2.63−1.36−1.62
Mapk8 PH_mM_0009123Mitogen-activated protein kinase 8, JNK1.82−1.14−1.22−1.04−1.24
Mapk13 PH_mM_0004240Mitogen-activated protein kinase 13, P381.39−2.27−1.89−2.10−1.50
Tnf mMC016605Tumor necrosis factor, TNF-α5.47−3.86−5.03−4.58−4.60
Il1b mMC010962Interleukin 1 beta, IL-1β3.69−2.92−4.27−2.33−2.47
Cxcr2 PH_mMC_0000540Chemokine (C-X-C motif) receptor 2, IL-81.93−2.80−3.25−2.25−2.22
Ccl5 mMC0118383Chemokine (C-C motif) ligand 5, RANTES3.51−0.93−3.39 −1.95−2.26
Tgfb1 PH_mMC_0001301Transforming growth factor, beta 11.46−0.84−1.25−0.92 −1.35
Csf2 mMC014357Colony stimulating factor 2 2.41−1.40−2.03−1.43−2.19
Il18 mMC021817Interleukin 18, IL-182.02−0.66−1.10−0.76−1.26
Il12a PH_mM_0009192Interleukin 12a, IL-123.38−3.32−2.92−2.91−3.05

Fold change. The intensity ratio of probe signal criteria for differential expressions was defined as a twofold change (up or down) (log2 FC ≥ 1 or ≤−1) in gene expression compared with virus control group and a value less than 0.05 in at least one time point as a minimum requirement to select. For instance, log2 (M/N) ≥ 1 means that the comparison between normal control group and virus control group was scattered, indicating that a large number of genes in virus control group were up-regulated in response to H1N1 infection. log2 (SH/M) ≤−1, log2 (SM/M) ≤−1, log2 (SL/M) ≤−1, and log2 (Oseltamivir/M) ≤−1 means that down-regulation in gene expression attributable to the high-dose SFXF group treatment, medium-dose group SFXF treatment, low-dose SFXF group treatment, and Oseltamivir group treatment was done by comparing genes in virus control group, respectively ( value data not shown).