Table 3: Genes associated with antigen processing presentation.

SymbolGenBank accessionGene descriptionlog2 FCa
M/NSH/MSM/MSL/MOseltamivir/M

Tap1 PH_mM_0000666Transporter 1, ATP-binding cassette, subfamily B (MDR/TAP)2.24−0.30−2.83−0.41−1.00
Tap2 mMC017161Transporter 2, ATP-binding cassette, subfamily B (MDR/TAP)2.29−0.02−2.27−0.20−1.05
Cd74 PH_mM_0016294CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), also as CLIP1.740.470.600.13−0.75
Ctsb PH_mM_0013880Cathepsin B1.47−0.27−0.95−0.24−0.54
Ctss PH_mM_0009536Cathepsin S1.990.29−1.39−0.28−0.90
Hspa5 mMC021274Heat shock protein 51.270.780.220.29−0.16
Hspa1a PH_mM_0000552Heat shock protein 1A2.05−0.17−2.39−0.67−0.75
Hspa1b PH_mM_0001288Heat shock protein 1B1.530.63−1.08−0.47−0.18
H2-M2 PH_mM_0002687Histocompatibility 2, M region locus 22.27−0.64−2.16−1.89−1.47
H2-M3 PH_mM_0009138Histocompatibility 2, M region locus 32.37−0.24−2.10−0.55−1.39
H2-Oa PH_mM_0000005Histocompatibility 2, O region alpha locus1.15−0.38−0.44−0.55−0.67
H2-Q10 PH_mM_0005188Histocompatibility 2, Q region locus 105.62−2.04−2.72−3.84−4.12
H2-Dma PH_mM_0005361Histocompatibility 2, class II, locus DMa1.49−0.17−1.11−0.43−1.14
H2-Eb1 PH_mM_0006643Histocompatibility 2, class II antigen E beta1.30−0.31−1.87−1.31−1.33
H2-Ab1 PH_mM_0006906Histocompatibility 2, class II antigen A, beta 11.170.26−0.050.33−0.10
Lgmn mMC007543Legumain2.270.08−1.10−0.24−0.83
Lta mMC008431Lymphotoxin A, TNF-β1.34−0.14−1.17−0.18−1.19
Psme1 PH_mM_0004486Proteasome (prosome, macropain) 28 subunit, alpha1.00−0.40−1.16−0.53−0.50
H2-T24 PH_mM_0007562Histocompatibility 2, T region locus 242.82−0.15−2.190.21−1.72
Psme2 PH_mM_0012374Proteasome (prosome, macropain) 28 subunit, beta1.99−1.00−1.55−1.58−1.00
Cd8a PH_mM_0015300CD8 antigen, alpha chain2.271.20−1.65−0.42−1.05
Cd8b1 mMC017400CD8 antigen, beta chain 12.491.31−1.18−1.58−0.73
Cd4 mMC002333CD4 antigen1.05−0.32−1.11−0.92−1.00

Fold change. The intensity ratio of probe signal criteria for differential expressions was defined as a twofold change (up or down) (log2 FC ≥ 1 or ≤−1) in gene expression compared with virus control group and a value less than 0.05 in at least one time point as a minimum requirement to select. For instance, log2 (M/N) ≥ 1 means that the comparison between normal control group and virus control group was scattered, indicating that a large number of genes in virus control group were up-regulated in response to H1N1 infection. log2 (SH/M) ≤−1, log2 (SM/M) ≤ −1, log2 (SL/M) ≤ −1, and log2 (Oseltamivir/M) ≤ −1 means that down-regulation in gene expression attributable to the high-dose SFXF group treatment, medium-dose group SFXF treatment, low-dose SFXF group treatment, and Oseltamivir group treatment was done by comparing genes in virus control group, respectively ( value data not shown).