Gene Expression Profiles Underlying Selective T-Cell-Mediated Immunity Activity of a Chinese Medicine Granule on Mice Infected with Influenza Virus H1N1
Table 3
Genes associated with antigen processing presentation.
Symbol
GenBank accession
Gene description
log2 FCa
M/N
SH/M
SM/M
SL/M
Oseltamivir/M
Tap1
PH_mM_0000666
Transporter 1, ATP-binding cassette, subfamily B (MDR/TAP)
2.24
−0.30
−2.83
−0.41
−1.00
Tap2
mMC017161
Transporter 2, ATP-binding cassette, subfamily B (MDR/TAP)
2.29
−0.02
−2.27
−0.20
−1.05
Cd74
PH_mM_0016294
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), also as CLIP
1.74
0.47
0.60
0.13
−0.75
Ctsb
PH_mM_0013880
Cathepsin B
1.47
−0.27
−0.95
−0.24
−0.54
Ctss
PH_mM_0009536
Cathepsin S
1.99
0.29
−1.39
−0.28
−0.90
Hspa5
mMC021274
Heat shock protein 5
1.27
0.78
0.22
0.29
−0.16
Hspa1a
PH_mM_0000552
Heat shock protein 1A
2.05
−0.17
−2.39
−0.67
−0.75
Hspa1b
PH_mM_0001288
Heat shock protein 1B
1.53
0.63
−1.08
−0.47
−0.18
H2-M2
PH_mM_0002687
Histocompatibility 2, M region locus 2
2.27
−0.64
−2.16
−1.89
−1.47
H2-M3
PH_mM_0009138
Histocompatibility 2, M region locus 3
2.37
−0.24
−2.10
−0.55
−1.39
H2-Oa
PH_mM_0000005
Histocompatibility 2, O region alpha locus
1.15
−0.38
−0.44
−0.55
−0.67
H2-Q10
PH_mM_0005188
Histocompatibility 2, Q region locus 10
5.62
−2.04
−2.72
−3.84
−4.12
H2-Dma
PH_mM_0005361
Histocompatibility 2, class II, locus DMa
1.49
−0.17
−1.11
−0.43
−1.14
H2-Eb1
PH_mM_0006643
Histocompatibility 2, class II antigen E beta
1.30
−0.31
−1.87
−1.31
−1.33
H2-Ab1
PH_mM_0006906
Histocompatibility 2, class II antigen A, beta 1
1.17
0.26
−0.05
0.33
−0.10
Lgmn
mMC007543
Legumain
2.27
0.08
−1.10
−0.24
−0.83
Lta
mMC008431
Lymphotoxin A, TNF-β
1.34
−0.14
−1.17
−0.18
−1.19
Psme1
PH_mM_0004486
Proteasome (prosome, macropain) 28 subunit, alpha
1.00
−0.40
−1.16
−0.53
−0.50
H2-T24
PH_mM_0007562
Histocompatibility 2, T region locus 24
2.82
−0.15
−2.19
0.21
−1.72
Psme2
PH_mM_0012374
Proteasome (prosome, macropain) 28 subunit, beta
1.99
−1.00
−1.55
−1.58
−1.00
Cd8a
PH_mM_0015300
CD8 antigen, alpha chain
2.27
1.20
−1.65
−0.42
−1.05
Cd8b1
mMC017400
CD8 antigen, beta chain 1
2.49
1.31
−1.18
−1.58
−0.73
Cd4
mMC002333
CD4 antigen
1.05
−0.32
−1.11
−0.92
−1.00
Fold change. The intensity ratio of probe signal criteria for differential expressions was defined as a twofold change (up or down) (log2 FC ≥ 1 or ≤−1) in gene expression compared with virus control group and a value less than 0.05 in at least one time point as a minimum requirement to select. For instance, log2 (M/N) ≥ 1 means that the comparison between normal control group and virus control group was scattered, indicating that a large number of genes in virus control group were up-regulated in response to H1N1 infection. log2 (SH/M) ≤−1, log2 (SM/M) ≤ −1, log2 (SL/M) ≤ −1, and log2 (Oseltamivir/M) ≤ −1 means that down-regulation in gene expression attributable to the high-dose SFXF group treatment, medium-dose group SFXF treatment, low-dose SFXF group treatment, and Oseltamivir group treatment was done by comparing genes in virus control group, respectively ( value data not shown).