Review Article

Shen Song Yang Xin Capsule Combined with Antiarrhythmic Drugs, a New Integrative Medicine Therapy, for the Treatment of Frequent Premature Ventricular Contractions (FPVC): A Meta-Analysis of Randomized Controlled Trials

Table 1

Characteristics and methodological quality of the included studies.

StudySample size (treatment/control)Diagnosis standard ComplicationsInterventionControlTreatment course (month)Clinical standardsOutcome measure

Huang 2009
[13]
64 (32/32)Diagnosis criteria for FPVC
(>720/24 h)
Elderly FPVCSSYX Capsule 1.6 g tid
+ Control
Amiodarone
200 mg, tid for 4 d; 200 mg, bid for 3 d; 200 mg, qd for 14 d; 100 mg, qd for maintenance treatment
1Clinical research guideline of medicine for cardiovascular system by Ministry of Public Health (1998)Total effect for FPVC; ADR
Guo
2008
[14]
26 (13/13)Diagnosis criteria for FPVC
(unclear)
FPVCSSYX Capsule 1.6 g tid
+ Control
Amiodarone
200 mg, tid for 7 d; 200 mg, bid for 7 d; 200 mg, qd for maintenance treatment
3Clinical research guideline of medicine for cardiovascular system by Ministry of Public Health (1998)Total effect for FPVC; ADR
Zhu et al. 2012
[15]
49 (28/21)ACC/AHA/HRS
(2008)
Sick Sinus Syndrome and FPVCSSYX Capsule 1.6 g tid
+ Control 
Conventional therapy with antiarrhythmic drugs (no detailed information)2Clinical research guideline of medicine for cardiovascular system by Ministry of Public Health (1998)Total effect for FPVC; Number of Ventricular Premature Beat; ADR
Ping et al. 2012 [16]56 (28/28)Diagnosis criteria for FPVC
(>720/24 h)
FPVCSSYX Capsule 1.6 g tid
+ Control
Amiodarone
200 mg, tid for 7 d; 200 mg, bid for 14 d; 200 mg, qd for maintenance treatment
4Clinical research guideline of medicine for cardiovascular system by Ministry of Public Health (1998)Total effect for FPVC
Su and Wang 2007
[17]
60 (30/30)Diagnosis criteria for FPVC
(>30/h)
FPVCSSYX Capsule 1.6 g tid
+ Control
Mexiletine
12.5 mg, bid
4Clinical research guideline of medicine for cardiovascular system by Ministry of Public Health (1998)Total effect for FPVC; Number of Ventricular Premature Beat; ADR
Yu et al. 2009
[18]
62 (32/30)Diagnosis criteria for FPVC
(>5/min)
FPVCSSYX Capsule 1.6 g tid
+ Control
Metoprolol
12.5 mg, bid
2Clinical research guideline of medicine for cardiovascular system by Ministry of Public Health (1998)Total effect for FPVC
Zhou and Li 2011
[19]
70 (35/35)Diagnosis criteria for FPVC
(>30/h)
FPVCSSYX Capsule 1.6 g tid
+ Control
Metoprolol
12.5 mg, bid
124 h HolterTotal effect for FPVC; Number of Ventricular Premature Beat
Geng et al. 2011
[20]
70 (35/35)Diagnosis criteria for FPVC
(>1000/24 h)
Elderly FPVCSSYX Capsule 1.6 g tid
+ Control
Metoprolol
12.5 mg, bid
4Clinical research guideline of medicine for cardiovascular system by Ministry of Public Health (1998)Total effect for FPVC; Number of Ventricular Premature Beat; ADR
Zhou 2013
[21]
36 (18/18)Diagnosis criteria for FPVC
(unclear)
FPVCSSYX Capsule 1.6 g tid
+ Control
Metoprolol
12.5 mg, bid
224 h HolterTotal effect for FPVC
Wan 2012
[22]
38 (20/18)Diagnosis criteria for FPVC
(unclear)
FPVCSSYX Capsule 1.6 g tid
+ Control
Metoprolol
12.5 mg, bid
424 h HolterTotal effect for FPVC; ADR
Fu et al. 2010
[23]
204 (106/98)Diagnosis criteria for FPVC
(7200/24 h)
FPVCSSYX Capsule 1.6 g tid
+ Control
Amiodarone
200 mg, tid for 3 d; 100 mg, bid for 3 d; 100 mg, qd for maintenance treatment
6Clinical research guideline of medicine for cardiovascular system by Ministry of Public Health (1998)Total effect for FPVC; ADR
Qiu et al. 2012
[24]
65 (33/32)Diagnosis criteria for FPVC
(>30/h)
FPVCSSYX Capsule 1.6 g tid
+ Control
Metoprolol
12.5 mg, bid
2Clinical research guideline of medicine for cardiovascular system by Ministry of Public Health (1998)Total effect for FPVC; Number of Ventricular Premature Beat; ADR
Li and Yan 2009
[25]
60 (30/30)Diagnosis criteria for FPVC
(unclear)
FPVCSSYX Capsule 1.6 g tid
+ Control
Propafenone
150 mg, tid
3Clinical research guideline of medicine for cardiovascular system by Ministry of Public Health (1998)Total effect for FPVC
Fu et al. 2010
[26]
72 (37/35)Diagnosis criteria for FPVC
(>30/h)
Elderly FPVCSSYX Capsule 1.6 g tid
+ Control
Amiodarone
200 mg, tid for 7 d; 200 mg, bid for 14 d; 200 mg, qd for 21 d; 100–200 mg, qd for maintenance treatment
4Clinical research guideline of medicine for cardiovascular system by Ministry of Public Health (1998)Total effect for FPVC; ADR
Zhang et al. 2011 [27]128 (64/64)Diagnosis criteria for FPVC
(unclear)
FPVCSSYX Capsule 1.6 g tid
+ Control
Metoprolol
12.5 mg, bid
4Clinical research guideline of medicine for cardiovascular system by Ministry of Public Health (1998)Total effect for FPVC; ADR
Liu and Li 2011
[28]
55 (30/25)Diagnosis criteria for FPVC
(unclear)
Elderly FPVCSSYX Capsule 1.6 g tid
+ Control
Propafenone
100–150 mg, tid
2Clinical research guideline of medicine for cardiovascular system by Ministry of Public Health (1998)Total effect for FPVC